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心脏手术后心肌顿抑会降低每搏功,但对于射血分数正常的患者,心脏输出功率保持不变。

Post cardiac surgery stunning reduces stroke work, but leaves cardiac power output unchanged in patients with normal ejection fraction.

作者信息

Tannvik Tomas D, Rimehaug Audun E, Skjaervold Nils K, Kirkeby-Garstad Idar

机构信息

Department of Anaesthesia and Intensive Care, St Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.

Faculty of Medicine and Health Sciences, Institute of Circulation and Medical Imaging, Norges Teknisk-Naturvitenskapelige Universitet, Trondheim, Norway.

出版信息

Physiol Rep. 2018 Jul;6(13):e13781. doi: 10.14814/phy2.13781.

Abstract

This study assesses positional changes in cardiac power output and stroke work compared with classic hemodynamic variables, measured before and after elective coronary artery bypass graft surgery. The hypothesis was that cardiac power output was altered in relation to cardiac stunning. The study is a retrospective analysis of data from two previous studies performed in a tertiary care university hospital. Thirty-six patients scheduled for elective coronary artery bypass graft surgery, with relatively preserved left ventricular function, were included. A pulmonary artery catheter and a radial artery catheter were placed preoperatively. Cardiac power output and stroke work were calculated through thermodilution both supine and standing prior to induction of anesthesia and again day one postoperatively. Virtually all systemic hemodynamic parameters changed significantly from pre- to postoperatively, and from supine to standing. Cardiac power output was maintained at 0.9-1.0 (±0.3) W both pre- and postoperatively and from supine to standing on both days. Stroke work fell from pre- to postoperatively from 1.1 to 0.8 J (P < 0.001), there was a significant fall in stroke work with positional change preoperatively from 1.1 to 0.9 J (P < 0.001). Postoperatively the stroke work remained at 0.8 J despite positional change. Cardiac power output was the only systemic hemodynamic variable which remained unaltered during all changes. Stroke work appears to be a more sensitive marker for temporary cardiovascular dysfunction than cardiac power output. Further studies should explore the relationship between stroke work and cardiac performance and whether cardiac power output is an autoregulated intrinsic physiological parameter.

摘要

本研究评估了择期冠状动脉旁路移植手术前后测量的心脏功率输出和每搏功与经典血流动力学变量相比的位置变化。假设是心脏功率输出与心脏顿抑有关。该研究是对在一家三级护理大学医院进行的两项先前研究的数据进行的回顾性分析。纳入了36例计划进行择期冠状动脉旁路移植手术且左心室功能相对保留的患者。术前放置肺动脉导管和桡动脉导管。在麻醉诱导前以及术后第一天,通过热稀释法计算仰卧位和站立位时的心脏功率输出和每搏功。几乎所有全身血流动力学参数在术前和术后以及从仰卧位到站立位时都有显著变化。心脏功率输出在术前和术后以及两天内从仰卧位到站立位均维持在0.9 - 1.0(±0.3)W。每搏功从术前的1.1 J降至术后的0.8 J(P < 0.001),术前体位改变时每搏功从1.1 J显著降至0.9 J(P < 0.001)。术后尽管体位改变,每搏功仍维持在0.8 J。心脏功率输出是所有变化过程中唯一保持不变的全身血流动力学变量。每搏功似乎是比心脏功率输出更敏感的临时心血管功能障碍标志物。进一步的研究应探讨每搏功与心脏功能之间的关系,以及心脏功率输出是否是一种自动调节的内在生理参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ec/6041697/75f0ac481bad/PHY2-6-e13781-g001.jpg

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