Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Central Laboratory, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Nanomedicine (Lond). 2018 Sep;13(17):2187-2199. doi: 10.2217/nnm-2018-0165. Epub 2018 Jul 12.
In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with a polypropylene (PP) material to generate a new type of mesh for hernia repair.
MATERIALS & METHODS: The PLA/PP mesh was tested with tensile testing, in vitro cytocompatibility and degradation. A total of 90 rats were randomly allocated to PLA/PP, PP and polyester (PE) mesh groups for the in vivo study to evaluate the properties of PLA/PP mesh.
PLA/PP mesh had superior mechanical properties. It also resulted in less inflammation adhesion formation (p < 0.05), which was related to the TGF-β1/Smad pathway. The distribution of collagen I and III in PLA/PP mesh was also superior to those in the other two groups (p < 0.05).
The PLA/PP mesh would be suitable for ventral hernia repair in the future.
本研究通过静电纺丝技术将聚乳酸（PLA）纳米纤维支架与聚丙烯（PP）材料相结合，制备出一种新型疝修补网片。
对 PLA/PP 网片进行拉伸试验、体外细胞相容性和降解试验。将 90 只大鼠随机分为 PLA/PP、PP 和聚酯（PE）网片组，进行体内研究，以评估 PLA/PP 网片的性能。
PLA/PP 网片具有优异的力学性能，且导致炎症粘连形成减少（p < 0.05），这与 TGF-β1/Smad 通路有关。PLA/PP 网片中 I 型和 III 型胶原的分布也优于其他两组（p < 0.05）。
PLA/PP 网片将来可能适用于腹疝修补。
