Kaewpinta Adchareeya, Khongkhunthian Sakornrat, Chaijareenont Pisaisit, Okonogi Siriporn
Interdisciplinary Program in Nanoscience and Nanotechnology, The Graduate School, Chiang Mai University.
Research Center of Pharmaceutical Nanotechnology, Chiang Mai University.
Drug Discov Ther. 2018;12(3):126-132. doi: 10.5582/ddt.2018.01023.
Carbamide peroxide (CP) is commonly used as a tooth whitening agent. However, efficacy of CP can be enhanced if it is in the suitable delivery system. In the present study, CP loaded in pigmented rice gels were developed and investigated for their physicochemical properties and tooth whitening efficacy. The modified pigmented rice of two varieties, Homnil (HN) and Doisket (DS) were prepared and used as a gelling agent. The outer appearance of the obtained rice gels containing 10% CP (CP-HN and CP-DS, respectively) were transparent and homogeneous texture. The pH of both rice gel bases was neutral but became slightly acidic after incorporating with CP. The adhesive property of HN gel was significantly higher than DS gels. In vitro drug release profile exhibited that the release of CP from CP-DS was significantly higher than CP-HN and the commercial gel (CP-CG), respectively. In vitro tooth whitening efficacy in 45 normal teeth revealed that the tooth whitening efficacy of the gels was time dependent. At the end of the treatment, CP-HN showed significantly higher tooth whitening efficacy than CP-DS and CP-CG, respectively. It is concluded that the physicochemical properties, particularly the adhesive and dissolution properties, play an important role in the tooth whitening efficacy of the CP gels.
过氧化脲（CP）通常用作牙齿美白剂。然而，如果将其置于合适的递送系统中，CP的功效可以得到增强。在本研究中，制备了负载于有色米凝胶中的CP，并对其理化性质和牙齿美白功效进行了研究。制备了两个品种（Homnil，HN和Doisket，DS）的改性有色米，并用作胶凝剂。所获得的含有10%CP的米凝胶（分别为CP-HN和CP-DS）外观透明且质地均匀。两种米凝胶基质的pH值呈中性，但与CP混合后变为微酸性。HN凝胶的粘附性显著高于DS凝胶。体外药物释放曲线表明，CP从CP-DS中的释放分别显著高于CP-HN和市售凝胶（CP-CG）。对45颗正常牙齿进行的体外牙齿美白功效研究表明，凝胶的牙齿美白功效与时间有关。在治疗结束时，CP-HN的牙齿美白功效分别显著高于CP-DS和CP-CG。得出的结论是，理化性质，特别是粘附性和溶解性，在CP凝胶的牙齿美白功效中起重要作用。
