Kolseth Ingrid Benedicte Moss, Reine Trine Marita, Parker Krystina, Sudworth Amanda, Witczak Bartlomiej J, Jenssen Trond Geir, Kolset Svein Olav
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
J Diabetes Complications. 2017 Jan;31(1):245-252. doi: 10.1016/j.jdiacomp.2016.06.029. Epub 2016 Jul 5.
To investigate and describe the relationship between diabetic nephropathy and systemic inflammation in patients with type 1 diabetes mellitus (T1DM).
Patients with T1DM, with or without reduced renal function due to diabetic nephropathy, were included. Differences in inflammatory mediators, adhesion molecules, markers of endothelial dysfunction and subsets of monocytes were studied in patients with mean disease duration of 31years.
Patients with T1DM with and without renal failure were compared. Patients with nephropathy had increased plasma levels of proinflammatory monocytes, as well as circulatory PAI-1, syndecan-1, VEGF, IL-1β, IL-1Ra and CCL4. Peripheral blood mononuclear cells from patients with nephropathy numerically increased soluble ICAM and PAI-1 in co-culture with primary endothelial cells compared to cells from patients without nephropathy.
T1DM patients with kidney failure have higher levels of proinflammatory monocytes and circulatory inflammatory mediators compared to patients with T1DM alone. The results highlight the importance of inflammation and endothelial dysfunction in diabetic nephropathy with reduced GFR.
研究并描述1型糖尿病（T1DM）患者糖尿病肾病与全身炎症之间的关系。
纳入患有或未因糖尿病肾病导致肾功能减退的T1DM患者。对平均病程为31年的患者的炎症介质、黏附分子、内皮功能障碍标志物及单核细胞亚群的差异进行了研究。
对患有和未患肾衰竭的T1DM患者进行了比较。肾病患者的促炎单核细胞血浆水平升高，循环中的纤溶酶原激活物抑制剂-1（PAI-1）、多配体蛋白聚糖-1、血管内皮生长因子（VEGF）、白细胞介素-1β（IL-1β）、白细胞介素-1受体拮抗剂（IL-1Ra）和趋化因子配体4（CCL4）水平也升高。与无肾病患者的细胞相比，肾病患者的外周血单个核细胞与原代内皮细胞共培养时，可溶性细胞间黏附分子（ICAM）和PAI-1在数值上有所增加。
与单纯T1DM患者相比，患有肾衰竭的T1DM患者具有更高水平的促炎单核细胞和循环炎症介质。结果突出了炎症和内皮功能障碍在肾小球滤过率降低的糖尿病肾病中的重要性。
