No information is available on the clinical use of obiltoxaximab during breastfeeding. Because obiltoxaximab is a large protein molecule with a molecular weight of 148,000, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] Until more data become available, obiltoxaximab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[3]
目前尚无关于奥比特昔单抗在母乳喂养期间临床应用的信息。由于奥比特昔单抗是一种分子量为148,000的大蛋白质分子,其在乳汁中的含量可能非常低。[1]它也可能在婴儿胃肠道中部分被破坏,婴儿的吸收可能极少。[2]在获得更多数据之前,母乳喂养期间应谨慎使用奥比特昔单抗,尤其是在哺育新生儿或早产儿期间。产后至少等待2周再恢复治疗可能会减少药物向婴儿的转移。[3]