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山楂

Hawthorn

Abstract

Hawthorn ( species) leaves, fruit and flowers contain flavonoids and oligomeric proanthocyanidins. Some hawthorn products are standardized based on the content of these ingredients. Hawthorn's main use is for treating mild heart failure. One small, old study found a galactogogue effect with hawthorn flowers;[1] however, no scientifically valid clinical trials support this use. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[2,3] No data exist on the excretion of any components of hawthorn into breastmilk or on the safety and efficacy of hawthorn in nursing mothers or infants. Hawthorn is generally well tolerated in adults with dizziness being the most common adverse effect. It can possibly increase the effect of anticoagulants, digoxin and hypotensive medications. Other occasional reactions include nausea, fatigue, sweating, and rash. The German Commission E states that there is no known reason to contraindicate use of the flowers or leaves during breastfeeding, but the fruit should be avoided. Other sources recommend avoiding hawthorn during breastfeeding because of a lack of studies. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site.

摘要

山楂(品种)的叶、果实和花含有黄酮类化合物和低聚原花青素。一些山楂产品是根据这些成分的含量进行标准化的。山楂的主要用途是治疗轻度心力衰竭。一项小型的旧研究发现山楂花有催乳作用;[1]然而,没有科学有效的临床试验支持这种用途。催乳剂绝不能取代对影响乳汁分泌的可改变因素的评估和咨询。[2,3]没有关于山楂任何成分在母乳中的排泄情况的数据,也没有关于山楂对哺乳期母亲或婴儿的安全性和有效性的数据。山楂在成年人中一般耐受性良好,最常见的不良反应是头晕。它可能会增强抗凝剂、地高辛和降压药物的作用。其他偶尔出现的反应包括恶心、疲劳、出汗和皮疹。德国委员会E指出,没有已知理由禁止在哺乳期使用山楂花或叶,但应避免食用果实。其他资料来源建议在哺乳期避免食用山楂,因为缺乏相关研究。膳食补充剂不需要美国食品药品监督管理局进行广泛的上市前批准。制造商有责任确保安全性,但在膳食补充剂上市前不需要证明其安全性和有效性。膳食补充剂可能含有多种成分,标签上的成分或其含量与实际情况之间往往存在差异。制造商可能会与独立组织签约以验证产品或其成分的质量,但这并不能证明产品的安全性或有效性。由于上述问题,一种产品的临床试验结果可能不适用于其他产品。关于膳食补充剂的更详细信息可在LactMed网站的其他地方获取。

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