Al-Zaghal Abdullah, Mehdizadeh Seraj Siavash, Werner Thomas J, Gerke Oke, Høilund-Carlsen Poul F, Alavi Abass
Hospital of University of Pennsylvania, United States.
Odense University Hospital, Denmark.
J Nucl Med. 2018 Jul 12. doi: 10.2967/jnumed.118.213678.
The aim of this research study was to determine the role of F-Sodium fluoride (NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intra-cranial structures. We also examined the association of NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomical sites that are known to calcify with normal aging. A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by F-NaF PET/CT (CAMONA) clinical trial (38 females and 40 males) were included in this retrospective study. The mean age was 45.28 ±14.15 years (21-75). Mean standardized uptake values (SUVmean) was used to measure NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each ROI. Correlation analysis was conducted to assess the association between parameters. Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ±25 in the left choroid plexus, and 0.23±0.08 in the epithalamus. Significant positive correlations were present between NaF uptake and age in the right choroid plexus (r=0.61, < 0.0001), left choroid plexus (r=0.63, p<0.0001), and epithalamus (r=0.36, = 0.001). NaF uptake significantly correlated with HU in the right choroid plexus (r=0.52, < 0.0001), left choroid plexus (r=0.57, p<0.0001), and epithalamus (r=0.25, = 0.03). NaF could be used in the assessment of physiological calcification in several intracranial structures. We report significant associations between NaF uptake and aging as well as HU in the calcified choroid plexus and epithalamus. Our findings further support the growing interest to utilize NaF for detecting extra-osseous, molecular calcification, and this powerful probe has potential applications in the evaluation of various age-related, neurodegenerative brain processes.
本研究的目的是确定氟 - 氟化钠（NaF）PET/CT成像在评估颅内结构生理性分子钙化中的作用。我们还研究了在已知随正常衰老而钙化的某些解剖部位，NaF积聚与年龄以及亨氏单位（HU）之间的关联。本回顾性研究纳入了心血管分子钙化F - NaF PET/CT评估（CAMONA）临床试验中的78名健康受试者（38名女性和40名男性）。平均年龄为45.28±14.15岁（21 - 75岁）。使用平均标准化摄取值（SUVmean）来测量脉络丛和丘脑上部（松果体和缰核）中的NaF积聚情况。还对每个感兴趣区域（ROI）测量了最大HU值。进行相关性分析以评估各参数之间的关联。右侧脉络丛的平均SUVmean为0.42±0.26，左侧脉络丛为0.39±0.25，丘脑上部为0.23±0.08。在右侧脉络丛（r = 0.61，p < 0.0001）、左侧脉络丛（r = 0.63，p < 0.0001）和丘脑上部（r = 0.36，p = 0.001）中，NaF摄取与年龄之间存在显著正相关。在右侧脉络丛（r = 0.52，p < 0.0001）、左侧脉络丛（r = 0.57，p < 0.0001）和丘脑上部（r = 0.25，p = 0.03）中，NaF摄取与HU显著相关。NaF可用于评估多个颅内结构的生理性钙化。我们报告了在钙化的脉络丛和丘脑上部中，NaF摄取与衰老以及HU之间存在显著关联。我们的研究结果进一步支持了利用NaF检测骨外分子钙化的兴趣日益增加，并且这种强大的探针在评估各种与年龄相关的神经退行性脑过程中具有潜在应用。
