脉络丛钙化与人脑皮质小胶质细胞激活的相关性：一项多模态 PET、CT、MRI 研究。
Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study.
机构信息
From the Brain Health Imaging Institute (T.B., X.H.W., G.C.C., Y.L., L.Z., K.X., N.W., E.T., E.S., I.O., X.M., Q.R.R., T.M., A.G., L.G.)
From the Brain Health Imaging Institute (T.B., X.H.W., G.C.C., Y.L., L.Z., K.X., N.W., E.T., E.S., I.O., X.M., Q.R.R., T.M., A.G., L.G.).
出版信息
AJNR Am J Neuroradiol. 2023 Jul;44(7):776-782. doi: 10.3174/ajnr.A7903. Epub 2023 Jun 15.
BACKGROUND AND PURPOSE
The choroid plexus (CP) within the brain ventricles is well-known to produce cerebrospinal fluid (CSF). Recently, the CP has been recognized as critical in modulating inflammation. MRI-measured CP enlargement has been reported in neuroinflammatory disorders like MS as well as with aging and neurodegeneration. The basis of MRI-measured CP enlargement is unknown. On the basis of tissue studies demonstrating CP calcification as a common pathology associated with aging and disease, we hypothesized that previously unmeasured CP calcification contributes to MRI-measured CP volume and may be more specifically associated with neuroinflammation.
MATERIALS AND METHODS
We analyzed 60 subjects (43 healthy controls and 17 subjects with Parkinson's disease) who underwent PET/CT using C-PK11195, a radiotracer sensitive to the translocator protein expressed by activated microglia. Cortical inflammation was quantified as nondisplaceable binding potential. Choroid plexus calcium was measured via manual tracing on low-dose CT acquired with PET and automatically using a new CT/MRI method. Linear regression assessed the contribution of choroid plexus calcium, age, diagnosis, sex, overall volume of the choroid plexus, and ventricle volume to cortical inflammation.
RESULTS
Fully automated choroid plexus calcium quantification was accurate (intraclass correlation coefficient with manual tracing = .98). Subject age and choroid plexus calcium were the only significant predictors of neuroinflammation.
CONCLUSIONS
Choroid plexus calcification can be accurately and automatically quantified using low-dose CT and MRI. Choroid plexus calcification-but not choroid plexus volume-predicted cortical inflammation. Previously unmeasured choroid plexus calcium may explain recent reports of choroid plexus enlargement in human inflammatory and other diseases. Choroid plexus calcification may be a specific and relatively easily acquired biomarker for neuroinflammation and choroid plexus pathology in humans.
背景与目的
脑室内的脉络丛（CP）是众所周知的产生脑脊液（CSF）的地方。最近，CP 被认为在调节炎症中起着关键作用。MRI 测量的 CP 增大已在神经炎症性疾病（如多发性硬化症）以及衰老和神经退行性变中得到报道。MRI 测量的 CP 增大的基础尚不清楚。基于组织研究表明 CP 钙化是与衰老和疾病相关的常见病理学，我们假设以前未测量到的 CP 钙化有助于 MRI 测量的 CP 体积，并且可能与神经炎症更具体相关。
材料与方法
我们分析了 60 名受试者（43 名健康对照者和 17 名帕金森病患者），他们接受了使用 C-PK11195 的 PET/CT 检查，这是一种对激活的小胶质细胞表达的转位蛋白敏感的放射性示踪剂。皮质炎症通过非置换结合势进行量化。脉络丛钙通过在 PET 获得的低剂量 CT 上手动追踪以及使用新的 CT/MRI 方法自动测量。线性回归评估脉络丛钙、年龄、诊断、性别、脉络丛总体积和脑室体积对皮质炎症的贡献。
结果
全自动脉络丛钙定量准确（与手动追踪的组内相关系数=.98）。受试者年龄和脉络丛钙是唯一显著预测炎症的因素。
结论
使用低剂量 CT 和 MRI 可以准确且自动地量化脉络丛钙化。脉络丛钙化而不是脉络丛体积预测皮质炎症。以前未测量到的脉络丛钙可能解释了最近在人类炎症和其他疾病中报道的脉络丛增大。脉络丛钙化可能是人类神经炎症和脉络丛病理学的一个特异性且相对容易获得的生物标志物。
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