Alon Ido, Cassou Mathilde, Golan Orit Cherny, Ravitsky Vardit
Department of Development Economics, Autonomous University of Madrid, Madrid, Spain.
University of Montreal, Montreal, Canada.
J Assist Reprod Genet. 2024 Nov;41(11):2855-2875. doi: 10.1007/s10815-024-03229-z. Epub 2024 Aug 26.
This scoping review investigates the Ethical, Legal, and Social Implications (ELSI) of gamete donation, a critical facet of Assisted Reproductive Technologies, by analyzing the evolving research scope, methodological approaches, and the geographical skew in the literature. Despite the increased global uptake of donor gametes, current scholarship predominantly emanates from Western contexts and focuses on majoritized groups. This bias constrains the universality of research findings and limits their applicability across varied legal, cultural, and social contexts, underscoring a need for broader inclusivity.
We addressed 867 pivotal articles published between 1999 and 2019.
Our analysis reveals a discernible escalation in research volume, with 62% based on empirical research. The intellectual landscape unfolds into four dominant clusters: Regulatory Frameworks, Incentives, and Access; Family Dynamics and Genetic Linkages; Identity and Privacy in Donor Conception; and Cultural and Societal Attitudes towards GD. Each cluster highlights nuanced dimensions of gamete donation, from regulatory intricacies and psychological welfare to identity ethics and cultural perceptions.
Our findings advocate for a shift towards more globally representative and methodologically inclusive research. By integrating diverse cultural narratives and expanding geographical breadth, future research can offer holistic understandings of gamete donation, fostering equitable and culturally resonant practices and policies worldwide.
本综述通过分析不断演变的研究范围、方法以及文献中的地域偏差，探讨辅助生殖技术的一个关键方面——配子捐赠的伦理、法律和社会影响（ELSI）。尽管全球范围内对捐赠配子的接受度有所提高，但当前的学术研究主要来自西方背景，且集中于多数群体。这种偏差限制了研究结果的普遍性，并限制了它们在不同法律、文化和社会背景下的适用性，凸显了更广泛包容性的必要性。
我们研究了1999年至2019年间发表的867篇关键文章。
我们的分析显示研究数量有明显增长，其中62%基于实证研究。知识领域呈现出四个主要聚类：监管框架、激励措施与获取途径；家庭动态与基因联系；捐赠受孕中的身份与隐私；以及对配子捐赠的文化和社会态度。每个聚类都突出了配子捐赠的细微差别，从监管的复杂性和心理福利到身份伦理和文化认知。
我们的研究结果主张转向更具全球代表性和方法上更具包容性的研究。通过整合不同的文化叙述并扩大地理范围，未来的研究可以提供对配子捐赠的全面理解，在全球范围内促进公平且具有文化共鸣的实践和政策。
