路易体痴呆的发病率和共病情况：一项基于人群的队列研究。
Incidence and Comorbidity of Dementia with Lewy Bodies: A Population-Based Cohort Study.
作者信息
Yang Sheng-Kung, Chen Weishan, Su Chun-Hsien, Liu Chung-Hsiang
机构信息
Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan.
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
出版信息
Behav Neurol. 2018 May 29;2018:7631951. doi: 10.1155/2018/7631951. eCollection 2018.
BACKGROUND AND AIMS
Dementia with Lewy bodies (DLB) is the third most common form of dementia. Epidemiological studies of DLB in Taiwan are scarce. In this study, we estimated the incidence of DLB and comorbidity in the population of Taiwan.
METHODS
Data were obtained from the Taiwan National Health Insurance Research Database (NHIRD). DLB patients between 2000 and 2013 were enrolled in assessments of incidence and comorbidity.
RESULTS
The incidence of DLB was shown to be 7.10 per 100,000 person-years (95% CI = 6.63-7.59), which increased with age. The average age at diagnosis was 76.3, and this was higher for males than for females. The comorbidity rates of hypertension and hyperlipidemia in DLB patients were higher in females than in males.
CONCLUSIONS
Epidemiologic data from large-scale retrospective studies is crucial to the prevention of DLB.
背景与目的
路易体痴呆（DLB）是第三常见的痴呆类型。台湾地区关于DLB的流行病学研究较少。在本研究中，我们估计了台湾地区人群中DLB的发病率及合并症情况。
方法
数据来源于台湾国民健康保险研究数据库（NHIRD）。纳入2000年至2013年间的DLB患者进行发病率及合并症评估。
结果
DLB的发病率为每10万人年7.10例（95%可信区间=6.63-7.59），且随年龄增长而升高。诊断时的平均年龄为76.3岁，男性高于女性。DLB患者中女性高血压和高脂血症的合并症发生率高于男性。
结论
大规模回顾性研究的流行病学数据对DLB的预防至关重要。
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