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不可切除的近端食管癌患者中,食管支架置入术联合经皮内镜下胃造口术作为补充喂养途径的安全性和有效性。

Safety and efficacy of oesophageal stenting with simultaneous percutaneous endoscopic gastrostomy as a supplementary feeding route in unresectable proximal oesophageal cancer.

作者信息

Włodarczyk Janusz R, Kużdżał Jarosław

机构信息

Department of Thoracic and Surgical Oncology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.

出版信息

Wideochir Inne Tech Maloinwazyjne. 2018 Jun;13(2):176-183. doi: 10.5114/wiitm.2018.73361. Epub 2018 Feb 7.

DOI:10.5114/wiitm.2018.73361
PMID:30002749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6041576/
Abstract

INTRODUCTION

Proximally located oesophageal cancer poses an especially difficult problem in terms of restoration of patency and the stenting procedure. Supplementary percutaneous endoscopic gastrostomy (PEG) may be useful in these patients.

AIM

To assess the safety of the stenting procedure in the proximal oesophagus in patients with unresectable upper oesophageal cancer, performed simultaneously with PEG insertion.

MATERIAL AND METHODS

Patients with obstructing upper oesophageal tumours were scheduled for an oesophageal stenting procedure and simultaneous PEG insertion. Degree of dysphagia, body weight loss, daily energy requirement, body mass index and performance status before and after the stenting procedure as well as complications were assessed.

RESULTS

Forty-five patients aged 19-88 years were included in the study. Six of them had a fistula to the trachea and underwent stenting of the oesophagus or both the oesophagus and the airway. The technical success rate was 100%. Following the procedure all patients were able to swallow fluids and semi-liquids, and PEG was used as the primary feeding route. Body mass index increased from 20.4 to 21.1 (p = 0.0001), body weight gain improved from -10.1 to +2.0 kg and metabolic requirements improved (p = 0.0001). Also, the Karnofsky score improved significantly (56.7 vs. 65.1, p = 0.0001). Mean survival time was 133 days (range: 36-378).

CONCLUSIONS

Stenting of the proximal oesophagus with simultaneous PEG is a safe procedure, allowing the patients to resume oral intake of liquids whilst improving nutritional status and general performance, with an acceptable rate of complications.

摘要

引言

就恢复通畅性和支架置入手术而言,近端食管癌带来了一个特别棘手的问题。补充性经皮内镜下胃造口术(PEG)可能对这些患者有用。

目的

评估在无法切除的上段食管癌患者中,与PEG置入同时进行的近端食管支架置入手术的安全性。

材料与方法

将患有上段食管肿瘤梗阻的患者安排进行食管支架置入手术并同时置入PEG。评估支架置入手术前后的吞咽困难程度、体重减轻情况、每日能量需求、体重指数和体能状态以及并发症。

结果

45名年龄在19至88岁之间的患者纳入了研究。其中6人有气管瘘,接受了食管或食管与气道的支架置入。技术成功率为100%。手术后所有患者都能够吞咽液体和半液体食物,且PEG被用作主要的喂养途径。体重指数从20.4增加到21.1(p = 0.0001),体重增加从 -10.1 kg改善到 +2.0 kg,代谢需求得到改善(p = 0.0001)。此外,卡诺夫斯基评分显著提高(56.7对65.1,p = 0.0001)。平均生存时间为133天(范围:36 - 378天)。

结论

同时进行PEG的近端食管支架置入是一种安全的手术,能使患者恢复经口摄入液体,同时改善营养状况和总体体能,并发症发生率可接受。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/b3db4f66487b/WIITM-13-31768-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/a643683d6267/WIITM-13-31768-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/0af95789ae39/WIITM-13-31768-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/df9489407475/WIITM-13-31768-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/a501a7a7f912/WIITM-13-31768-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/b3db4f66487b/WIITM-13-31768-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/a643683d6267/WIITM-13-31768-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/0af95789ae39/WIITM-13-31768-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/df9489407475/WIITM-13-31768-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/a501a7a7f912/WIITM-13-31768-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3b/6041576/b3db4f66487b/WIITM-13-31768-g005.jpg

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