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纳米羟基磷灰石对运动员骨修复作用的研究

Study on the effect of nano-hydroxyapatite on bone repair of athletes.

作者信息

Wang Jianyong

机构信息

College of Physical Education, Zhengzhou Normal University, Zhengzhou, China.

出版信息

Wideochir Inne Tech Maloinwazyjne. 2018 Jun;13(2):221-226. doi: 10.5114/wiitm.2018.73973. Epub 2018 Mar 8.

DOI:10.5114/wiitm.2018.73973
PMID:30002755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6041591/
Abstract

INTRODUCTION

Minimally invasive surgery is a widely used method for bone repair. Nano-hydroxyapatite (n-HA) is a non-toxic and harmless bone repair material.

AIM

To study the repair effect of n-HA/PA66 on the lumbar vertebrae injury of basketball players.

MATERIAL AND METHODS

Firstly, the n-HA/PA66 material was prepared and its properties were studied. Then, the n-HA/PA66 material was used in a rabbit vertebral replacement experiment to study its bone coverage, fiber coverage and bone density. Afterwards, the material was used in vertebral injury treatment of basketball players to study its bone repairing effect.

RESULTS

It was found that the fiber coverage of artificial vertebral bodies of n-HA/PA66 material tended to decrease with the increase of replacement time but no significant difference was found in the fiber coverage at different times (p > 0.05); the longer the replacement time, the greater the bone coverage, with statistically significant differences (p < 0.05); as the replacement time increased, the density and osteogenic volume increased; the Japanese Orthopaedic Association (JOA) scoring both 3 months and 6 months after surgery was greater than that immediately after surgery, with a significant difference (p < 0.05); the difference of angle of Cobb showed a decreasing trend with the increase of replacement time, and there was a significant difference (p < 0.05); follow-up results showed that the subjects had no rejection reaction.

CONCLUSIONS

N-HA material played an important role in basketball players' bone repair treatment and is worth being promoted for application.

摘要

引言

微创手术是一种广泛应用于骨修复的方法。纳米羟基磷灰石（n-HA）是一种无毒无害的骨修复材料。

目的

研究n-HA/PA66对篮球运动员腰椎损伤的修复效果。

材料与方法

首先制备n-HA/PA66材料并研究其性能。然后将n-HA/PA66材料用于兔椎体置换实验，研究其骨覆盖率、纤维覆盖率和骨密度。之后将该材料用于篮球运动员的椎体损伤治疗，研究其骨修复效果。

结果

发现n-HA/PA66材料人工椎体的纤维覆盖率随置换时间的增加有下降趋势，但不同时间的纤维覆盖率差异无统计学意义（p>0.05）；置换时间越长，骨覆盖率越大，差异有统计学意义（p<0.05）；随着置换时间增加，密度和成骨体积增加；术后3个月和6个月的日本骨科学会（JOA）评分均高于术后即刻，差异有统计学意义（p<0.05）；Cobb角差异随置换时间增加呈下降趋势，差异有统计学意义（p<0.05）；随访结果显示受试者无排斥反应。

结论

n-HA材料在篮球运动员骨修复治疗中发挥了重要作用，值得推广应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/f45ac89c8446/WIITM-13-32064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/7b71d49d524c/WIITM-13-32064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/4f3e1751c684/WIITM-13-32064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/fca7011ba8d4/WIITM-13-32064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/bf13483f19ec/WIITM-13-32064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/a320c92702c8/WIITM-13-32064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/f45ac89c8446/WIITM-13-32064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/7b71d49d524c/WIITM-13-32064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/4f3e1751c684/WIITM-13-32064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/fca7011ba8d4/WIITM-13-32064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/bf13483f19ec/WIITM-13-32064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/a320c92702c8/WIITM-13-32064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d4/6041591/f45ac89c8446/WIITM-13-32064-g006.jpg

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