Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, 9054, New Zealand.
Department of Chemistry, University of Otago, Dunedin, 9054, New Zealand.
J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):2046-2057. doi: 10.1002/jbm.b.33950. Epub 2017 Jun 26.
Bone tissue engineering has emerged as one of the most indispensable approaches to address bone trauma in the past few decades. This approach offers an efficient and a risk-free alternative to autografts and allografts by employing a combination of biomaterials and cells to promote bone regeneration. Hydroxyapatite (HA) is a ceramic biomaterial that mimics the mineral composition of bones and teeth in vertebrates. HA, commonly produced via several synthetic routes over the years has been found to exhibit good bioactivity, biocompatibility, and osteoconductivity under both in vitro and in vivo conditions. However, the brittle nature of HA restricts its usage for load bearing applications. To address this problem, HA has been used in combination with several polymers in the form of biocomposite implants to primarily improve its mechanical properties and also enhance the implants' overall performance by simultaneously exploiting the positive effects of both HA and the polymer involved in making the biocomposite. This review article summarizes the past and recent developments in the evolution of HA-polymer biocomposite implants as an "ideal" biomaterial scaffold for bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2046-2057, 2018.
在过去的几十年中，骨组织工程已成为解决骨创伤的最不可或缺的方法之一。这种方法通过结合生物材料和细胞来促进骨再生，为自体移植物和同种异体移植物提供了一种高效且无风险的替代方法。羟基磷灰石（HA）是一种陶瓷生物材料，模拟脊椎动物骨骼和牙齿的矿物质组成。HA 多年来通过多种合成途径生产，已被发现具有良好的生物活性、生物相容性和骨诱导性，无论是在体外还是体内条件下。然而，HA 的脆性限制了其在承重应用中的使用。为了解决这个问题，已经将 HA 与几种聚合物以生物复合材料植入物的形式结合使用，主要是为了改善其机械性能，并通过同时利用 HA 和制造生物复合材料的聚合物的积极影响来提高植入物的整体性能。本文综述了过去和最近在 HA-聚合物生物复合材料植入物作为骨再生的“理想”生物材料支架的发展。 © 2017 Wiley Periodicals, Inc. J 生物材料研究杂志 B：应用生物材料，106B：2046-2057，2018。
