Costello Leslie C
School of Dentistry Department of Oncology and Diagnostic Sciences and the Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA.
J Can Res Updates. 2018;7(3):79-83. doi: 10.6000/1929-2279.2018.07.03.3. Epub 2018 Jun 25.
Although the availability of funding has been described as the major limitation on advances in cancer, the progress in the war on cancer has been deterred mainly by poor science, poorly trained scientists, and poor NIH policies. This is the result of NIH policies of its extreme focus on molecular biology (genomics, molecular genetics, molecular biology) identification of the molecular factors and pathways; which are required for the acceptability of treatment and preventive protocols. As such, this has influenced virtually all agencies that provide grants for medical research to adopt the NIH policies. This has impacted the funding of the research as well as the focus of the training of scientists. Directors of NCI Dr. Varmus (also Nobel Prize awardee) and Dr. Zerhouni had addressed this issue; and they rejected the necessity of molecular biology studies and information. NIH should return to the holistic physiological/pathophysiological approach to studies of cancer issues. This would provide the best approach for winning the war on cancer.
尽管资金的可获得性被描述为癌症进展的主要限制因素，但抗癌战争的进展主要受到糟糕的科学、训练不足的科学家以及美国国立卫生研究院（NIH）糟糕政策的阻碍。这是NIH极端专注于分子生物学（基因组学、分子遗传学、分子生物学）以识别分子因素和途径的政策导致的结果；而这些分子因素和途径是治疗和预防方案被认可所必需的。因此，这实际上影响了几乎所有为医学研究提供资助的机构采用NIH的政策。这对研究资金以及科学家的培训重点都产生了影响。美国国立癌症研究所（NCI）的所长瓦尔默斯博士（也是诺贝尔奖获得者）和泽胡尼博士已经谈到了这个问题；并且他们拒绝了分子生物学研究和信息的必要性。NIH应该回归到研究癌症问题的整体生理/病理生理方法。这将为赢得抗癌战争提供最佳途径。
