嘧啶酮治疗对致死性和免疫抑制性小鼠巨细胞病毒感染的影响。
Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.
作者信息
Brideau R J, Wolcott J A
出版信息
Antimicrob Agents Chemother. 1985 Oct;28(4):485-8. doi: 10.1128/AAC.28.4.485.
Abstract
The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Weanling mice infected with a sublethal challenge of CMV exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen concanavalin A. Treatment of mice with pyrimidinones during the course of CMV immunosuppression resulted in substantial augmentation of splenic cell blastogenic responses. The degree of augmentation appeared to be dependent on the severity of CMV-induced immunosuppression.
摘要
2-氨基-5-卤嘧啶酮是强效的干扰素诱导剂和抗病毒剂，研究发现，在病毒攻击前给药时，它们对断奶或新生小鼠的致死性巨细胞病毒（CMV）攻击具有保护作用。这种保护作用取决于嘧啶酮的给药剂量。用亚致死剂量的CMV感染的断奶小鼠表现出中度至重度免疫抑制，体外对促细胞分裂剂刀豆球蛋白A的脾细胞增殖反应降低可作为衡量指标。在CMV免疫抑制过程中用嘧啶酮治疗小鼠，可使脾细胞增殖反应大幅增强。增强程度似乎取决于CMV诱导的免疫抑制的严重程度。
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