小鼠脾脏中的巨细胞病毒感染及其与免疫抑制的关系。
Murine cytomegalovirus infection in the spleen and its relationship to immunosuppression.
作者信息
Loh L, Hudson J B
出版信息
Infect Immun. 1981 Jun;32(3):1067-72. doi: 10.1128/iai.32.3.1067-1072.1981.
Abstract
An attempt was made to correlate murine cytomegalovirus-induced immuno-suppression with the presence of virus-infected cells in the spleen. For this purpose, SWR/J mice were infected with murine cytomegalovirus, and spleens were removed periodically and assayed for the presence of infectious centers in different cell populations and for their capacity to respond to mitogens. The maximal degree of immunosuppression correlated with the peak in adherent cell infectious centers. This was followed by a rapid rise in the number of cells per spleen (splenomegaly), a more gradual return to normal responsiveness to mitogens, and a rapid disappearance of infectious centers. These results add more support to the hypothesis that murine cytomegalovirus-induced immunosuppression is caused indirectly by infection of adherent spleen cells.
摘要
人们试图将鼠巨细胞病毒诱导的免疫抑制与脾脏中病毒感染细胞的存在联系起来。为此，用鼠巨细胞病毒感染SWR/J小鼠，并定期切除脾脏，检测不同细胞群体中感染中心的存在情况及其对有丝分裂原的反应能力。免疫抑制的最大程度与黏附细胞感染中心的峰值相关。随后脾脏细胞数量迅速增加（脾肿大），对有丝分裂原的反应能力逐渐恢复正常，感染中心迅速消失。这些结果进一步支持了以下假说：鼠巨细胞病毒诱导的免疫抑制是由脾脏黏附细胞感染间接引起的。
相似文献
1
Murine cytomegalovirus infection in the spleen and its relationship to immunosuppression.小鼠脾脏中的巨细胞病毒感染及其与免疫抑制的关系。
Infect Immun. 1981 Jun;32(3):1067-72. doi: 10.1128/iai.32.3.1067-1072.1981.
2
Murine cytomegalovirus-induced immunosuppression.鼠巨细胞病毒引起的免疫抑制。
Infect Immun. 1982 Apr;36(1):89-95. doi: 10.1128/iai.36.1.89-95.1982.
3
Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection.新生巨细胞病毒感染豚鼠的胸腺发育不全、脾肿大及免疫抑制
Dev Comp Immunol. 1987 Spring;11(2):407-18. doi: 10.1016/0145-305x(87)90084-x.
4
Immunosuppressive effect of murine cytomegalovirus.鼠巨细胞病毒的免疫抑制作用
Infect Immun. 1980 Jan;27(1):54-60. doi: 10.1128/iai.27.1.54-60.1980.
5
Effects of cyclosporine on chronic cytomegalovirus infection in the guinea pig.环孢素对豚鼠慢性巨细胞病毒感染的影响。
Intervirology. 1987;28(3):171-80. doi: 10.1159/000150013.
6
Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.嘧啶酮治疗对致死性和免疫抑制性小鼠巨细胞病毒感染的影响。
Antimicrob Agents Chemother. 1985 Oct;28(4):485-8. doi: 10.1128/AAC.28.4.485.
7
Progressive inhibition of T-cell function preceding clinical signs of cytomegalovirus infection in mice.在小鼠巨细胞病毒感染临床症状出现之前，T细胞功能的渐进性抑制。
J Infect Dis. 1977 Mar;135(3):478-81. doi: 10.1093/infdis/135.3.478.
8
Asynchronous depression of responses to T- and B-cell mitogens during acute infection with cytomegalovirus in the guinea pig.豚鼠巨细胞病毒急性感染期间对T细胞和B细胞有丝分裂原反应的异步抑制
Cell Immunol. 1984 Sep;87(2):727-33. doi: 10.1016/0008-8749(84)90043-1.
9
Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice.自然杀伤细胞缺失小鼠中鼠巨细胞病毒感染的发病机制
J Virol. 1984 Oct;52(1):119-28. doi: 10.1128/JVI.52.1.119-128.1984.
10
Effect of murine cytomegalovirus on the in vitro responses of T and B cells to mitogens.鼠巨细胞病毒对T细胞和B细胞体外有丝分裂原反应的影响。
J Immunol. 1976 May;116(5):1459-65.
引用本文的文献
1
Immune surveillance of cytomegalovirus in tissues.组织中巨细胞病毒的免疫监视。
Cell Mol Immunol. 2024 Sep;21(9):959-981. doi: 10.1038/s41423-024-01186-2. Epub 2024 Aug 12.
2
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.髓系细胞通过 STAT1 限制 MCMV 并驱动应激诱导的骨髓外造血。
Cell Rep. 2019 Feb 26;26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017.
3
Cyclophilin A as a target in the treatment of cytomegalovirus infections.亲环素A作为巨细胞病毒感染治疗的靶点
Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618811413. doi: 10.1177/2040206618811413.
4
Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus.经胎盘传播的大鼠巨细胞病毒的发病机制及垂直传播
Virol J. 2006 Jun 1;3:42. doi: 10.1186/1743-422X-3-42.
5
Infection of laboratory rats with a new cytomegalo-like virus.用一种新的巨细胞病毒样病毒感染实验大鼠。
Arch Virol. 1983;76(3):189-99. doi: 10.1007/BF01311103.
6
Murine cytomegalovirus-induced immunosuppression.鼠巨细胞病毒引起的免疫抑制。
Infect Immun. 1982 Apr;36(1):89-95. doi: 10.1128/iai.36.1.89-95.1982.
7
Effect of murine cytomegalovirus infection on mitogen responses in genetically resistant and susceptible mice.鼠巨细胞病毒感染对基因抗性和易感小鼠有丝分裂原反应的影响。
Infect Immun. 1982 Apr;36(1):235-42. doi: 10.1128/iai.36.1.235-242.1982.
8
Characterization of the guinea pig cytomegalovirus genome by molecular cloning and physical mapping.通过分子克隆和物理图谱分析豚鼠巨细胞病毒基因组
J Virol. 1984 Nov;52(2):436-47. doi: 10.1128/JVI.52.2.436-447.1984.
9
Animal viruses of economic importance: genetic variation, persistence, and prospects for their control.具有经济重要性的动物病毒：遗传变异、持续性及其防控前景
Pharmacol Ther. 1985;30(2):115-226. doi: 10.1016/0163-7258(85)90033-6.
10
Comparison of serological tests for the detection of antibody to natural and experimental murine cytomegalovirus.用于检测天然和实验性鼠巨细胞病毒抗体的血清学检测方法比较
Can J Vet Res. 1987 Apr;51(2):249-52.
本文引用的文献
1
Virulence and attenuation of murine cytomegalovirus.鼠巨细胞病毒的毒力和减毒。
Infect Immun. 1971 Feb;3(2):228-36. doi: 10.1128/iai.3.2.228-236.1971.
2
Immunosuppressive effect of murine cytomegalovirus.鼠巨细胞病毒的免疫抑制作用
Infect Immun. 1980 Jan;27(1):54-60. doi: 10.1128/iai.27.1.54-60.1980.
3
Cytomegalovirus-induced immune suppression. II. Cell-mediated immunity.巨细胞病毒诱导的免疫抑制。II. 细胞介导的免疫
Clin Exp Immunol. 1974 Sep;18(1):119-26.
4
Cytomegalovirus-induced immune suppression. I. Humoral immunity.巨细胞病毒诱导的免疫抑制。I. 体液免疫。
Clin Exp Immunol. 1974 Sep;18(1):109-18.
5
Immunosuppression during acute murine cytomegalovirus infection.急性小鼠巨细胞病毒感染期间的免疫抑制
J Immunol. 1968 Apr;100(4):835-44.
6
Some properties of the genome of murine cytomegalovirus (MCV).鼠巨细胞病毒（MCV）基因组的一些特性。
Virology. 1973 Jul;54(1):135-49. doi: 10.1016/0042-6822(73)90123-2.
7
Enzyme immunoassays in diagnostic medicine. Theory and practice.诊断医学中的酶免疫测定。理论与实践。
Bull World Health Organ. 1976;53(1):55-65.
8
Rapid diagnosis of tick-borne encephalitis by means of enzyme linked immunosorbent assay.通过酶联免疫吸附测定法快速诊断蜱传脑炎。
J Gen Virol. 1979 Mar;42(3):505-11. doi: 10.1099/0022-1317-42-3-505.
9
The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections.鼠巨细胞病毒作为研究病毒发病机制和持续性感染的模型。
Arch Virol. 1979;62(1):1-29. doi: 10.1007/BF01314900.
10
Interaction of murine cytomegalovirus with separated populations of spleen cells.小鼠巨细胞病毒与分离的脾细胞群体的相互作用。
Infect Immun. 1979 Dec;26(3):853-60. doi: 10.1128/iai.26.3.853-860.1979.
Zotero 插件