Carney W P, Rubin R H, Hoffman R A, Hansen W P, Healey K, Hirsch M S
J Immunol. 1981 Jun;126(6):2114-6.
Lymphocyte proliferative responses to mitogens and herpes virus antigens are diminished during cytomegalovirus (CMV) mononucleosis. We analyzed peripheral blood T lymphocytes from patients in the acute and convalescent phases of CMV mononucleosis using monoclonal antibodies directed against the T helper and the T cytotoxic-suppressor cell subsets. Acute CMV infection is associated with a reversal in the normal ratio of helper to suppressor T lymphocytes with relative and absolute decreases in T helper cells and corresponding increases in T suppressor cells. These alterations in T lymphocyte subsets are accompanied by diminished lymphocyte responses to the mitogen concanavalin A (Con A). During convalescence, helper T lymphocytes increase, suppressor T lymphocytes decrease, and Con A responses return to normal.
在巨细胞病毒（CMV）单核细胞增多症期间，淋巴细胞对有丝分裂原和疱疹病毒抗原的增殖反应减弱。我们使用针对T辅助细胞和T细胞毒性抑制细胞亚群的单克隆抗体，分析了CMV单核细胞增多症急性期和恢复期患者的外周血T淋巴细胞。急性CMV感染与辅助性T淋巴细胞与抑制性T淋巴细胞的正常比例发生逆转有关，T辅助细胞相对和绝对减少，而T抑制细胞相应增加。T淋巴细胞亚群的这些改变伴随着淋巴细胞对有丝分裂原刀豆球蛋白A（Con A）的反应减弱。在恢复期，辅助性T淋巴细胞增加，抑制性T淋巴细胞减少，Con A反应恢复正常。
