Lucchelli Juan Pablo, Bertschy Gilles
Ville-Evrard Hospital, Neuilly-sur-Marne 93330, France.
Laboratory of Clinical Psychopathology, E.A. 4050 University of Rennes 2, Rennes, France.
Case Rep Psychiatry. 2018 May 30;2018:6278501. doi: 10.1155/2018/6278501. eCollection 2018.
Autism Spectrum Disorder (ASD) is defined by the copresence of two core symptoms: alteration in social communication and repetitive behaviors and/or restricted interests. In ASD children and adults, irritability, self-injurious behavior (SIB), and Attention Deficit and Hyperactivity Disorders- (ADHD-) like symptoms are regularly observed. In these situations, pharmacological treatments are sometimes used. Selective Serotonin Reuptake Inhibitors- (SSRI-) based treatments have been the subject of several publications: case reports and controlled studies, both of which demonstrate efficacy on the symptoms mentioned above, even if no consensus has been reached concerning their usage. In this article four clinical cases of children diagnosed with ASD and who also present ADHD-like symptoms and/or SIB and/or other heteroaggressive behaviors or irritability and impulsivity treated with low doses of fluoxetine are presented.
自闭症谱系障碍（ASD）由两种核心症状共同存在来定义：社交沟通改变以及重复行为和/或兴趣受限。在患有ASD的儿童和成人中，经常会观察到易怒、自伤行为（SIB）以及类似注意力缺陷多动障碍（ADHD）的症状。在这些情况下，有时会采用药物治疗。基于选择性5-羟色胺再摄取抑制剂（SSRI）的治疗方法已有多篇文献报道：包括病例报告和对照研究，两者均表明对上述症状有效，尽管在其使用方面尚未达成共识。本文介绍了4例被诊断为ASD且伴有类似ADHD症状和/或SIB和/或其他异质性攻击行为或易怒及冲动症状的儿童，他们接受了低剂量氟西汀治疗的临床病例。
