Klakk Heidi, Kristensen Peter Lund, Andersen Lars Bo, Froberg Karsten, Møller Niels Christian, Grøntved Anders
University of Southern Denmark, Department of Sport Science and Clinical Biomechanics, Research Unit for Exercise Epidemiology, Centre of Research in Childhood Health, Denmark.
University College Lillebælt, Department of Physiotherapy, Odense, Denmark.
Prev Med Rep. 2018 May 22;11:209-215. doi: 10.1016/j.pmedr.2018.05.017. eCollection 2018 Sep.
Depression in young adults is a growing concern to public health. This study aims to investigate if depression status in young adults is related to clinical and behavioral cardiovascular disease (CVD) risk factors. Cross-sectional data from a population-based sample of young Danish adults participating in the European Youth Heart Study 2009-2010 were used to examine this (n = 644, mean age 24.3 years 47% male). Measures of cardiorespiratory fitness (CRF), body composition, blood pressure, fasting levels of high and low density lipids (HDL, LDL), insulin, and glucose were obtained. Symptoms of depression were obtained using the Major Depression Inventory scale. Information on sleep disorders; drinking and smoking habits were obtained by questionnaires. Associations of depression with CVD risk factors were examined using logistic and linear regression adjusted for age and sex. Prevalence of mild-moderate-severe depression was 8.7% (5.6% males, 11.5% females). Significant sex differences were found in the association between several CVD risk factors and depression status. Women with depression had higher odds of overweight (OR = 2.2, 95%CI: 1.01-4.0), abdominal adiposity (OR = 2.5, 95%CI: 1.2-4.8), low CRF (OR = 2.5, 95%CI: 1.2-5.5), insulin resistance (OR = 2.3, 95%CI: 1.1-4.6), low HDL (OR = 2.0, 95%CI: 1.01-4.1) and high LDL (OR = 2.2, 95%CI: 1.04-4.5) compared to women without depression. Men with depression had significantly increased odds of having high blood pressure and being smokers compared to men without depression (OR: 3.1, 95%CI: 1.1-8.8 and OR: 3.0, 95%CI: 1.1-8.4, respectively). Depression symptoms in young adulthood were related to unfavorable clinical- and behavioral CVD risk factors, particularly in women.
青年抑郁症日益引起公众健康关注。本研究旨在调查青年抑郁症状态是否与临床和行为性心血管疾病（CVD）危险因素相关。采用2009 - 2010年参与欧洲青年心脏研究的丹麦青年人群样本的横断面数据进行此项研究（n = 644，平均年龄24.3岁，男性占47%）。获取了心肺适能（CRF）、身体成分、血压、高低密度脂蛋白（HDL、LDL）、胰岛素和葡萄糖的空腹水平等测量值。使用重度抑郁量表获取抑郁症状。通过问卷调查获取睡眠障碍、饮酒和吸烟习惯等信息。采用经年龄和性别调整的逻辑回归和线性回归分析抑郁与CVD危险因素之间的关联。轻度 - 中度 - 重度抑郁症患病率为8.7%（男性5.6%，女性11.5%）。在几种CVD危险因素与抑郁状态之间的关联中发现了显著的性别差异。与无抑郁的女性相比，抑郁女性超重（OR = 2.2，95%CI：1.01 - 4.0）、腹部肥胖（OR = 2.5，95%CI：1.2 - 4.8）、CRF低（OR = 2.5，95%CI：1.2 - 5.5）、胰岛素抵抗（OR = 2.3，95%CI：1.1 - 4.6）、HDL低（OR = 2.0，95%CI：1.01 - 4.1）和LDL高（OR = 2.2，95%CI：1.04 - 4.5）的几率更高。与无抑郁的男性相比，抑郁男性患高血压和吸烟的几率显著增加（OR分别为：3.1，95%CI：1.1 - 8.8和OR：3.0，95%CI：1.1 - 8.4）。青年期的抑郁症状与不良的临床和行为性CVD危险因素相关，尤其是在女性中。
