Rhee Sang Jin, Kim Eun Young, Kim Se Hyun, Lee Hyun Jeong, Kim Bora, Ha Kyooseob, Yoon Dae Hyun, Ahn Yong Min
Department of Psychiatry, Seoul National University Hospital, Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea.
Institute of Human Behavioral Medicine, Medical Research Institute, Seoul National University, Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:223-30. doi: 10.1016/j.pnpbp.2014.06.006. Epub 2014 Jun 27.
The evidence of the association between depression and metabolic syndrome is increasing, but the existence of sex differences in this association remains controversial. The aim of this study was to investigate the association between subjective depressive symptoms and metabolic syndrome and each of its components by sex in the Korean population.
The study sample comprised 15,073 men and 15,034 women who underwent routine health examinations. They completed the Beck Depression Inventory for depressive symptoms, and medical examinations provided data regarding metabolic syndrome. Adjustments for age, marriage, cigarette smoking, alcohol use, exercise, education, cancer, stroke, angina, and thyroid disease were performed. The association between depressive symptoms and metabolic syndrome and each of its components was analyzed by multiple logistic regression.
In women, depressive symptoms were associated with metabolic syndrome (OR=1.35, 95% CI=1.11-1.64, p=0.002) and the high-density lipoprotein cholesterol component (OR=1.26, 95% CI=1.09-1.46, p=0.002) of metabolic syndrome. There was also an association between the severity of depressive symptoms and metabolic syndrome in women (OR=1.046, 95% CI=1.002-1.091, p=0.039). In men, depressive symptoms were inversely associated with the hypertension component of metabolic syndrome (OR=0.73, 95% CI=0.58-0.91, p=0.005).
Subjective depressive symptoms were associated with metabolic syndrome only in women. Further research should consider sex differences and dyslipidemia.
抑郁症与代谢综合征之间关联的证据日益增多，但这种关联中性别差异的存在仍存在争议。本研究的目的是调查韩国人群中主观抑郁症状与代谢综合征及其各组成部分之间的性别关联。
研究样本包括15073名男性和15034名女性，他们接受了常规健康检查。他们完成了用于评估抑郁症状的贝克抑郁量表，医学检查提供了有关代谢综合征的数据。对年龄、婚姻状况、吸烟、饮酒、运动、教育程度、癌症、中风、心绞痛和甲状腺疾病进行了校正。通过多元逻辑回归分析抑郁症状与代谢综合征及其各组成部分之间的关联。
在女性中，抑郁症状与代谢综合征（比值比=1.35，95%置信区间=1.11-1.64，p=0.002）以及代谢综合征的高密度脂蛋白胆固醇组分（比值比=1.26，95%置信区间=1.09-1.46，p=0.002）相关。女性抑郁症状的严重程度与代谢综合征之间也存在关联（比值比=1.046，95%置信区间=1.002-1.091，p=0.039）。在男性中，抑郁症状与代谢综合征中的高血压组分呈负相关（比值比=0.73，95%置信区间=0.58-0.91，p=0.005）。
主观抑郁症状仅在女性中与代谢综合征相关。进一步的研究应考虑性别差异和血脂异常。
