Azzi Alain Joe, Gornitsky Jordan, Viezel-Mathieu Alex, Lessard Lucie
Division of Plastic and Reconstructive Surgery, McGill University Faculty of Medicine, Montreal, QC, Canada.
Department of Medicine, McGill University Faculty of Medicine, Montreal, QC, Canada.
J Cancer Prev. 2018 Jun;23(2):93-98. doi: 10.15430/JCP.2018.23.2.93. Epub 2018 Jun 30.
There is a paucity of data comparing the oncologic properties of breast cancer among patients previously having undergone breast augmentation in either the subglandular or subpectoral planes. The objective of the present systematic review was to evaluate whether implant location influenced the characteristics of breast tumors in previously augmented women.
A systematic literature search was performed to identify relevant articles reporting tumor characteristics in augmented patients. The search included published articles in three electronic databases; Ovid MEDLINE, EMBASE, and PubMed. Comparative studies (subglandular vs. subpectoral) were included.
Analysis of data pooled from the included studies showed that subglandular implants had a higher frequency of tumors between 2 to 5 cm (26.5% vs. 9.9%, = 0.0130). Subglandular implants also had a higher frequency of stage 2 tumors (42.9% vs. 23.7%, = 0.0308). There was no significant difference in lymphovascular invasion between the 2 groups. These results of this systematic review suggest that the prognosis of patients undergoing augmentation is unaffected by implant location (subpectoral vs. subglandular).
With the absence of large randomized controlled trials, our study provides surgeons with an evidence-based reference to improve informed consent with regards to implant placement.
目前缺乏关于曾在乳腺下或胸肌下平面进行隆胸手术的患者中乳腺癌肿瘤学特性比较的数据。本系统评价的目的是评估植入物位置是否会影响曾隆胸女性的乳腺肿瘤特征。
进行系统的文献检索，以识别报告隆胸患者肿瘤特征的相关文章。检索包括三个电子数据库中的已发表文章；Ovid MEDLINE、EMBASE和PubMed。纳入比较研究（乳腺下与胸肌下）。
对纳入研究汇总数据的分析表明，乳腺下植入物的肿瘤在2至5厘米之间的频率更高（26.5%对9.9%，P = 0.0130）。乳腺下植入物的II期肿瘤频率也更高（42.9%对23.7%，P = 0.0308）。两组之间的淋巴管浸润无显著差异。本系统评价的这些结果表明，隆胸患者的预后不受植入物位置（胸肌下与乳腺下）的影响。
由于缺乏大型随机对照试验，我们的研究为外科医生提供了基于证据的参考，以改善关于植入物放置的知情同意。
