Prabhu D Sathya, Selvam A Panneer, Rajeswari V Devi
Department of Biomedical sciences, School of Biosciences and Technology, VIT University, Vellore 14, Tamil Nadu, India.
Department of Zoology, Thiruvalluvar University, Serkadu, Vellore 14, Tamil Nadu, India.
Biochem Biophys Rep. 2018 Jun 28;15:39-44. doi: 10.1016/j.bbrep.2018.06.004. eCollection 2018 Sep.
Natural products are vital in drug discovery and the search for anticancer agents has been significant importance to the researchers for a long time. In the present study, aqueous leaf extract of was evaluated for its cytotoxic activity. The leaf extract was preliminarily screened for antioxidant activity using DPPH method for Radical Scavenging Activity, Hydrogen Peroxide Scavenging Activity and Reducing Power Activity. Further, the aqueous leaf extract was screened for cytotoxic activity against breast cancer cell lines (MCF-7) in vitro. The results of the study showed that aqueous extract of the leaf was rich in phytochemicals, antioxidant activity and showed a significant anti-cancer activity against tested MCF-7 cell lines. The present study was designed to evaluate the anticancer potential of leaf. The antioxidants present in have strong cytotoxic activity suggests that it can be considered for anti-cancer treatment.
天然产物在药物发现中至关重要，长期以来，寻找抗癌药物一直是研究人员的重要工作。在本研究中，对[植物名称]的叶水提取物的细胞毒性活性进行了评估。使用DPPH法对叶提取物进行自由基清除活性、过氧化氢清除活性和还原能力活性的抗氧化活性初步筛选。此外，对叶水提取物进行了体外抗乳腺癌细胞系（MCF-7）的细胞毒性活性筛选。研究结果表明，[植物名称]叶的水提取物富含植物化学物质，具有抗氧化活性，并对测试的MCF-7细胞系显示出显著的抗癌活性。本研究旨在评估[植物名称]叶的抗癌潜力。[植物名称]中存在的抗氧化剂具有很强的细胞毒性活性，这表明它可被考虑用于抗癌治疗。
