Headache Group, Department of Basic and Clinical Neuroscience, King's College London, and NIHR-Wellcome Trust King's Clinical Research Facility, King's College Hospital, Denmark Hill, London, SE5 9PJ, UK.
Department of Neuroscience, St. Agostino Estense Hospital, University of Modena and Reggio Emilia, via P. Giardini 1355, 41100, Modena, Italy.
J Headache Pain. 2018 Jul 13;19(1):50. doi: 10.1186/s10194-018-0875-x.
Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders. In this review, we explore the historical background of medication-overuse headache, its epidemiology, phenomenology, pathophysiology and treatment options. The review explores relevant unanswered questions and summarizes the current debates in medication-overuse headache.
药物过度使用性头痛是一种全球性现象，在头痛障碍的慢性化过程中起作用。由于高成本和合并症，个人和社会的疾病负担很大。在《国际头痛疾病分类》第三版中，药物过度使用性头痛被认为是仅次于大多数原发性头痛疾病的单独继发性疾病实体，尽管许多临床医生认为该疾病是原发性头痛疾病的唯一并发症。在这篇综述中，我们探讨了药物过度使用性头痛的历史背景、流行病学、表现、病理生理学和治疗选择。综述探讨了相关的未解决问题，并总结了药物过度使用性头痛的当前争议。
