Semenova N V, Madaeva I M, Bairova T A, Zhambalova R M, Kalyuzhnaya O V, Rashidova M A, Kolesnikova L I
Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2018 Jul;165(3):331-333. doi: 10.1007/s10517-018-4162-2. Epub 2018 Jul 12.
We carried out a comparative analysis of circadian rhythms of melatonin secretion in Caucasian menopausal women with and without insomnia depending on the 3111T/C polymorphism of the Clock gene. Melatonin levels was measured in the saliva 4 times a day (06.00-07.00, 12.00-13.00, 18.00-19.00, and 23.00-00.00 h). Carriers of the TT genotype with insomnia demonstrated significantly higher level of melatonin in the early morning hours compared to the carriers of the minor allele C (12.60±7.58 and 8.98±8.62 pg/ml, respectively, p=0.023). In the control group, no statistically significant differences were revealed. The carriers of the TT genotype with sleep disorders have higher morning melatonin level compared to control group women (12.60±7.58 and 5.48±4.74 pg/ml, respectively, p=0.005) and low nocturnal melatonin level (6.42±4.97 and 12.52±10.40 pg/ml, respectively, p=0.039).
我们根据生物钟基因（Clock基因）的3111T/C多态性，对患有和未患有失眠症的白种绝经后女性褪黑素分泌的昼夜节律进行了比较分析。每天在唾液中测量4次褪黑素水平（06:00 - 07:00、12:00 - 13:00、18:00 - 19:00和23:00 - 00:00时）。患有失眠症的TT基因型携带者在清晨时段的褪黑素水平显著高于次要等位基因C的携带者（分别为12.60±7.58和8.98±8.62 pg/ml，p = 0.023）。在对照组中，未发现有统计学意义的差异。患有睡眠障碍的TT基因型携带者与对照组女性相比，早晨褪黑素水平较高（分别为12.60±7.58和5.48±4.74 pg/ml，p = 0.00），夜间褪黑素水平较低（分别为6.42±4.97和12.52±10.40 pg/ml，p = 0.039）。
