Semenova N V, Madaeva I M, Bairova T I, Ershova O A, Kalyuzhnaya O V, Korytov L I, Kolesnikova L I
Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):461-464. doi: 10.1007/s10517-017-3828-5. Epub 2017 Aug 29.
Comparative analysis of the frequency distributions of genotypes and alleles of 3111T/C Clock gene polymorphism was carried out in climacteric Caucasian women with and without insomnia. Genotype TT is more incident in women with insomnia (55.5% vs. 42.6% in the control). Allele T predominated in the control and study group and its frequency is higher in women with insomnia. The OR for the risk of insomnia realization is 1.78 (95%CI 1.16-2.75). No association between genotypes and complaints of patients with insomnia is detected.
对3111T/C时钟基因多态性的基因型和等位基因频率分布进行了比较分析，研究对象为患有和未患有失眠症的更年期白种女性。基因型TT在失眠女性中更为常见（55.5%，而对照组为42.6%）。等位基因T在对照组和研究组中占主导地位，且其频率在失眠女性中更高。失眠发生风险的比值比为1.78（95%置信区间1.16 - 2.75）。未检测到基因型与失眠患者主诉之间的关联。
