极性头部基团取代对C6神经胶质细胞中磷脂甲基化及β-肾上腺素能反应的影响。
The effect of polar head group substitution on phospholipid methylation and the beta-adrenergic response in C6 glial cells.
作者信息
McKenzie R C, Gillespie C S, Brophy P J
出版信息
Biochem J. 1985 Nov 1;231(3):769-71. doi: 10.1042/bj2310769.
Abstract
The membranes of intact C6 cells were enriched with phosphatidyldimethylethanolamine or phosphatidylmonomethylethanolamine. These cells showed enhanced rates of phospholipid methylation but this was not accompanied by an increased beta-adrenergic response. We conclude that phospholipid methylation is not coupled to the activation of adenylate cyclase in the beta-adrenergic response of C6 glial cells.
摘要
完整的C6细胞的细胞膜富含磷脂酰二甲基乙醇胺或磷脂酰单甲基乙醇胺。这些细胞显示出磷脂甲基化速率增强，但这并未伴随着β-肾上腺素能反应的增加。我们得出结论，在C6神经胶质细胞的β-肾上腺素能反应中，磷脂甲基化与腺苷酸环化酶的激活没有关联。
相似文献
1
The effect of polar head group substitution on phospholipid methylation and the beta-adrenergic response in C6 glial cells.极性头部基团取代对C6神经胶质细胞中磷脂甲基化及β-肾上腺素能反应的影响。
Biochem J. 1985 Nov 1;231(3):769-71. doi: 10.1042/bj2310769.
2
3
Phospholipid methylation: a possible mechanism of signal transduction across biomembranes.磷脂甲基化：跨生物膜信号转导的一种可能机制。
Prog Clin Biol Res. 1981;63:383-8.
4
Presence of phospholipid-N-methyltransferases and base-exchange enzymes in rat central nervous system axolemma-enriched fractions.
J Neurochem. 1984 Oct;43(4):1018-24. doi: 10.1111/j.1471-4159.1984.tb12838.x.
5
Evidence against a requirement for phospholipid methylation in adenylate cyclase activation by hormones. Methyltransferase inhibitors do not impair cyclic AMP accumulation induced by glucagon or beta-adrenergic agents in rat hepatocytes.反对激素激活腺苷酸环化酶过程中磷脂甲基化必要性的证据。甲基转移酶抑制剂不会损害胰高血糖素或β-肾上腺素能药物诱导大鼠肝细胞中环磷酸腺苷的积累。
FEBS Lett. 1982 Feb 22;138(2):167-72. doi: 10.1016/0014-5793(82)80433-x.
6
Guanosine 5'-triphosphate modulation of S-adenosyl-L-methionine-mediated methylation of phosphatidylethanolamine in rat liver plasma membrane.鸟苷 5'-三磷酸对大鼠肝质膜中 S-腺苷-L-甲硫氨酸介导的磷脂酰乙醇胺甲基化的调节作用
Biochem Biophys Res Commun. 1983 Jul 18;114(1):425-30. doi: 10.1016/0006-291x(83)91644-3.
7
Age dependent changes in the methylation of rat brain phospholipids.大鼠脑磷脂甲基化的年龄依赖性变化。
Brain Res. 1981 Dec 14;229(1):256-9. doi: 10.1016/0006-8993(81)90767-8.
8
Phospholipid methyltransferase activity in diabetic rat fat cells: effect of isoproterenol and insulin.糖尿病大鼠脂肪细胞中的磷脂甲基转移酶活性：异丙肾上腺素和胰岛素的作用。
Mol Cell Biochem. 1992 Sep 22;115(1):97-103. doi: 10.1007/BF00229101.
9
beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.β-肾上腺素能受体激动剂可增加磷脂甲基化、膜流动性以及β-肾上腺素能受体与腺苷酸环化酶的偶联。
Proc Natl Acad Sci U S A. 1979 Jan;76(1):368-72. doi: 10.1073/pnas.76.1.368.
10
Absence of a direct role of phospholipid methylation in stimulus-secretion coupling and control of adenylate cyclase in guinea-pig and rat parotid gland.磷脂甲基化在豚鼠和大鼠腮腺的刺激-分泌偶联及腺苷酸环化酶调控中无直接作用。
Biochem J. 1982 Oct 15;208(1):205-10. doi: 10.1042/bj2080205.
引用本文的文献
本文引用的文献
1
The possible functional significance of phosphatidylethanolamine methylation.磷脂酰乙醇胺甲基化可能的功能意义。
Nature. 1980 Nov 20;288(5788):277-9. doi: 10.1038/288277a0.
2
Phospholipid methylation in MOPC-31C cell membranes with modified phospholipid composition.具有修饰磷脂组成的MOPC-31C细胞膜中的磷脂甲基化
Biochem Biophys Res Commun. 1980 Sep 30;96(2):876-81. doi: 10.1016/0006-291x(80)91437-0.
3
Early increases in phospholipid methylation are not necessary for the mitogenic stimulation of lymphocytes.磷脂甲基化的早期增加对于淋巴细胞的有丝分裂原刺激并非必要。
J Biol Chem. 1982 Jul 25;257(14):8183-9.
4
Nerve growth factor stimulates phospholipid methylation in growing neurites.神经生长因子刺激正在生长的神经突中的磷脂甲基化。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7797-800. doi: 10.1073/pnas.78.12.7797.
5
Pitfalls and problems in studies on the methylation of phosphatidylethanolamine.磷脂酰乙醇胺甲基化研究中的陷阱与问题。
J Biol Chem. 1983 Sep 10;258(17):10695-701.
6
Calcium signals and phospholipid methylation in eukaryotic cells.真核细胞中的钙信号与磷脂甲基化
Biochem J. 1984 Aug 1;221(3):675-84. doi: 10.1042/bj2210675.
7
Insulin stimulation of phospholipid methylation in isolated rat adipocyte plasma membranes.胰岛素对分离的大鼠脂肪细胞质膜中磷脂甲基化的刺激作用。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1089-92. doi: 10.1073/pnas.81.4.1089.
8
Lipid composition and physical properties of membranes from C-6 glial cells with altered phospholipid polar headgroups.磷脂极性头部基团发生改变的C-6神经胶质细胞膜的脂质组成和物理性质。
Biochim Biophys Acta. 1984 Jan 25;769(2):357-62. doi: 10.1016/0005-2736(84)90317-1.
9
Isoproterenol stimulates lipid methylation in C6 cells without affecting membrane fluidity.异丙肾上腺素刺激C6细胞中的脂质甲基化，而不影响膜流动性。
FEBS Lett. 1983 Dec 12;164(2):244-6. doi: 10.1016/0014-5793(83)80294-4.
10
What is the function of phospholipid N-methylation?磷脂N-甲基化的功能是什么？
Biochem J. 1983 Jul 1;213(1):1-10. doi: 10.1042/bj2130001.
Zotero 插件