Crews F T, Calderini G, Battistella A, Toffano G
Brain Res. 1981 Dec 14;229(1):256-9. doi: 10.1016/0006-8993(81)90767-8.
Phospholipid methyltransferase I and II enzymes methylate phosphatidylethanolamine three times to form phosphatidylcholine. The activity of these two enzymes was determined in synaptosome-enriched fractions from rats 1, 3, 7, 15 and 21 months old. The activity of phospholipid methyltransferase I was significantly greater in 7-, 15- and 21-month-old rats than in 1- and 3-month-old rats. In contrast, the activity of phospholipid methyltransferase II did not change with age. These changes in methyltransferase activity with increasing age may be related to changes in beta-receptor function with increasing age.
磷脂甲基转移酶I和II可将磷脂酰乙醇胺甲基化三次，形成磷脂酰胆碱。在1、3、7、15和21月龄大鼠富含突触体的组分中测定了这两种酶的活性。7、15和21月龄大鼠的磷脂甲基转移酶I活性显著高于1和3月龄大鼠。相比之下，磷脂甲基转移酶II的活性不随年龄变化。随着年龄增长，甲基转移酶活性的这些变化可能与β受体功能随年龄增长的变化有关。
