基于塑料闪烁体的微流控器件用于正电子发射断层扫描放射性药物的微型化检测。

Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals.

机构信息

Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

School of Mathematics and Physical Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

出版信息

Chemistry. 2018 Sep 18;24(52):13749-13753. doi: 10.1002/chem.201802395. Epub 2018 Aug 20.

DOI:10.1002/chem.201802395

PMID:30003615

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [ F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

摘要

一种微型化的放射性 HPLC 检测器已经研发出来，它由塑料闪烁体与硅光电倍增管光传感器组合而成的微流控装置构成，并已使用含有正电子放射性核素 [ F]氟化物的样品进行了测试。这种具有成本效益、占地面积小的分析工具非常适合整合到正电子发射断层扫描 (PET) 放射性药物的质量控制系统中，以符合良好生产规范 (GMP) 标准。