Xie Honghu, Lu Qicheng, Wang Haitao, Zhu Xianbo, Guan Zhong
Department of Gastrointestinal Surgery, The First People's Hospital of Changzhou, Changzhou, China.
J BUON. 2018 May-Jun;23(3):678-683.
To explore the therapeutic effect of probiotics combined with enteral nutrition (ΕΝ) in postoperative patients with gastric cancer (GC).
140 GC patients were enrolled in this study and randomly assigned into the test group and the control group, with 70 patients in each group. Patients in the test group were treated with probiotics combined with ΕΝ, while those in the control group were treated with common ΕΝ. Patients' conditions were observed for 8 days. IgG, IgA, IgM, IL-6, IL- 8, TNF-α, hemoglobin, albumin, pre-albumin, time to relief of abdominal distension, time to first flatus, length of hospital stay and adverse events were recorded and analyzed.
The factors related to immune function in patients of the test group, such as IgG, IgA and IgM, were higher than those of the control group. Moreover, the improvements of inflammatory cytokines including IL-6, IL-8 and TNF-α in patients of the test group were better than those of the control group. However, no obvious difference was found in the nutritional status before and after treatment between the two groups (p>0.05). In the comparison of clinical symptoms, time to relief of abdominal distention and time to first flatus were both earlier in patients of the test group than in those of the control group (p=0.002, p=0.03, respectively). Additionally, the diarrhea caused by ΕΝ was also significantly less in the test group compared with the probiotics control (p=0.03).
Probiotics combined with ΕΝ could improve the immune function and reduce the inflammatory response and the incidence of diarrhea in postoperative patients with gastric cancer.
探讨益生菌联合肠内营养（EN）对胃癌（GC）术后患者的治疗效果。
本研究纳入140例GC患者，随机分为试验组和对照组，每组70例。试验组患者采用益生菌联合EN治疗，对照组患者采用普通EN治疗。观察患者8天的病情。记录并分析IgG、IgA、IgM、IL-6、IL-8、TNF-α、血红蛋白、白蛋白、前白蛋白、腹胀缓解时间、首次排气时间、住院时间及不良事件。
试验组患者的免疫功能相关因子如IgG、IgA和IgM高于对照组。此外，试验组患者炎症细胞因子IL-6、IL-8和TNF-α的改善情况优于对照组。然而，两组治疗前后的营养状况无明显差异（p>0.05）。在临床症状比较中，试验组患者腹胀缓解时间和首次排气时间均早于对照组（分别为p=0.002，p=0.03）。此外，试验组因EN引起的腹泻也明显少于益生菌对照组（p=0.03）。
益生菌联合EN可改善胃癌术后患者的免疫功能，减轻炎症反应，降低腹泻发生率。
