Department of Animal Science and Technology, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, China; National Gene Bank of Waterfowl Resources, Taizhou 225300, China.
Department of Animal Science and Technology, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, China.
Poult Sci. 2020 Apr;99(4):1838-1846. doi: 10.1016/j.psj.2019.11.053. Epub 2020 Feb 25.
In poultry, viral infections (e.g., Marek's disease virus, avian leukosis virus, influenza A virus, and so on) can cause devastating mortality and economic losses. Because viruses are solely dependent on host cells to propagate, they alter the host intracellular microenvironment. Thus, understanding the virus-host interaction is important for antiviral immunity and drug development in the poultry industry. MicroRNAs are crucial posttranscriptional regulators of gene expression in a wide spectrum of biological processes, including viral infection. Recently, microRNAs have been identified as key players in virus-host interactions. In this review, we will discuss the intricacies involved in the virus-host cross-talk mediated by host and viral microRNAs in poultry (i.e., chicken and ducks), as well as recent trends and challenges in this field. These findings may provide some insights into the rapidly developing area of research regarding viral pathogenesis and antiviral immunity in poultry production.
在禽类中，病毒感染（例如马立克氏病病毒、禽白血病病毒、甲型流感病毒等）可导致毁灭性的死亡率和经济损失。由于病毒只能依赖宿主细胞进行繁殖，因此它们会改变宿主细胞的内部微环境。因此，了解病毒-宿主相互作用对于禽类产业中的抗病毒免疫和药物开发非常重要。microRNAs 是广泛的生物学过程（包括病毒感染）中基因表达的重要转录后调控因子。最近，microRNAs 已被确定为病毒-宿主相互作用中的关键参与者。在本综述中，我们将讨论宿主和病毒 microRNAs 介导的禽类（即鸡和鸭）病毒-宿主交叉对话的复杂性，以及该领域的最新趋势和挑战。这些发现可能为禽类生产中病毒发病机制和抗病毒免疫的快速发展领域的研究提供一些思路。
