Icer Mehmet Arif, Gezmen-Karadag Makbule
Gazi University, Faculty of Health Sciences, Nutrition and Dietetics Department, 06500 Beşevler, Ankara, Turkey.
Clin Biochem. 2018 Sep;59:17-24. doi: 10.1016/j.clinbiochem.2018.07.003. Epub 2018 Jul 10.
Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.
骨桥蛋白（OPN）是一种高度磷酸化的糖磷蛋白，具有酸性特征且富含天冬氨酸。OPN作为一种多功能蛋白，在心血管疾病、癌症、糖尿病和肾结石疾病以及炎症、生物矿化、细胞活力和伤口愈合过程中具有重要作用。骨桥蛋白通过在白细胞介素-10（IL-10）、白细胞介素-12（IL-12）、白细胞介素-3（IL-3）、干扰素-γ（IFN-γ）、整合素αvB3、核因子κB（NF-κB）、巨噬细胞和T细胞的分泌水平中发挥关键作用，来作用于生物体，调节破骨细胞功能并影响CD44受体。本综述的目的是探讨通过关于该蛋白已获得的数据所知晓、怀疑或暗示的OPN蛋白的大多数不同功能。
