The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, South Korea; Divison of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
Immunol Lett. 2018 Nov;203:6-14. doi: 10.1016/j.imlet.2018.07.003. Epub 2018 Jul 9.
Osteoarthritis (OA) is a chronic and degenerative disease that causes pain, cartilage deformation, and joint inflammation. Lactobacillus species have been used as dietary supplements to induce the production of antimicrobial and anti-inflammatory factors. The goal of this study was to determine whether Lactobacillus acidophilus ameliorates monosodium iodoacetate-induced OA. L. acidophilus showed anti-nociceptive properties and protected against cartilage destruction. It also downregulated the levels of proinflammatory cytokines and increased the levels of anti-inflammatory cytokines in the joints of OA rats. L. acidophilus additionally restored the balance between anabolic and catabolic factors in chondrocytes from OA patients. These results suggest that L. acidophilus can alleviate OA-associated pain and delay the progression of the disease by inhibiting proinflammatory cytokine production and reducing cartilage damage.
骨关节炎（OA）是一种慢性退行性疾病，会引起疼痛、软骨变形和关节炎症。乳杆菌属已被用作膳食补充剂，以诱导产生抗菌和抗炎因子。本研究旨在确定嗜酸乳杆菌是否能改善单碘乙酸钠诱导的 OA。嗜酸乳杆菌表现出抗伤害感受特性，并能防止软骨破坏。它还能下调 OA 大鼠关节中促炎细胞因子的水平，增加抗炎细胞因子的水平。嗜酸乳杆菌还能恢复 OA 患者软骨细胞中合成代谢和分解代谢因子之间的平衡。这些结果表明，嗜酸乳杆菌通过抑制促炎细胞因子的产生和减少软骨损伤，可以缓解 OA 相关的疼痛并延缓疾病的进展。
