Cuneo Crovari P, Terragna A, Robert L, Orlando G, Rizzo F, Piuma-Fusco M, Icardi G C, Papa D, Di Ponzio A, Auteri G
Boll Ist Sieroter Milan. 1985;64(4):339-42.
Anti-HTLV III prevalence has been investigated in serum samples of 638 intravenous drug users collected over May 1981 - March 1985 and stored at -20 degrees C. Separately, in a prospective way, we have studied 68 IV drug abusers (53 Genoese and 15 of Sanremo area) of whom we have collected, at least, one serum specimen for each year, starting with 1981. We have also tested for anti-HTLV III presence serum samples of: 91 subjects of Hospital staff (Infectious Diseases Department and Laboratory workers); 32 workers in Therapeutic Communities for drug users and 24 family contacts of anti-HTLV III positive drug users. And then serum samples of two groups of general population collected for other seroepidemiological investigations in 1982 (256 subjects) and 1984 (538 subjects) were tested. No IV drug user was positive in 1981 whilst from 1982 up to 1984 there was a strong rising of the prevalence of anti-HTLV III positive subjects: 2, 22, and 39 per cent, respectively. The prevalence remained about 40% in the first months of 1985. The investigations carried out also show that HTLV III spread in Sanremo area slightly before than in Genoa and neighbourhood. No subject positive for anti-HTLV III has been detected among the Hospital staff and in workers of Therapeutic communities who have more probability to get in contact with infected subjects or their blood, as well as in the general population. A positive case has been discovered in a family contact (the wife of a positive for anti-HTLV III IV drug user). Some epidemiological and public health questions linked to the situation observed, at present, in Liguria, are discussed.
对1981年5月至1985年3月期间收集并保存在-20摄氏度的638名静脉吸毒者的血清样本进行了抗人类嗜T淋巴细胞病毒III型（Anti-HTLV III）流行率调查。另外，我们前瞻性地研究了68名静脉吸毒者（53名热那亚人和15名圣雷莫地区的人），从1981年开始，每年至少为他们每人收集一份血清样本。我们还检测了以下人员血清样本中的抗HTLV III：91名医院工作人员（传染病科和实验室工作人员）；32名戒毒治疗社区的工作人员以及24名抗HTLV III阳性吸毒者的家庭接触者。然后，检测了1982年（256名受试者）和1984年（538名受试者）为其他血清流行病学调查而收集的两组普通人群的血清样本。1981年没有静脉吸毒者呈阳性，而从1982年到1984年，抗HTLV III阳性受试者的流行率急剧上升，分别为2%、22%和39%。1985年头几个月，流行率仍保持在40%左右。所开展的调查还表明，HTLV III在圣雷莫地区的传播略早于热那亚及其周边地区。在医院工作人员、更有可能接触受感染对象或其血液的戒毒治疗社区工作人员以及普通人群中，均未检测到抗HTLV III呈阳性的个体。在一名家庭接触者（一名抗HTLV III阳性静脉吸毒者的妻子）中发现了一例阳性病例。讨论了与目前利古里亚地区观察到的情况相关的一些流行病学和公共卫生问题。
