Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
J Dermatol. 2018 Oct;45(10):1216-1220. doi: 10.1111/1346-8138.14538. Epub 2018 Jul 13.
Interleukin (IL)-34 is a hematopoietic cytokine promoting proliferation and differentiation of macrophages. Because abnormal activation of macrophages is involved in the development of systemic sclerosis (SSc), we investigated serum IL-34 levels in patients with SSc. Serum IL-34 levels were significantly increased in diffuse cutaneous SSc compared with limited cutaneous SSc and healthy controls, while there were no significant differences between limited cutaneous SSc and healthy controls. In addition, SSc patients with increased serum IL-34 levels more often had interstitial lung disease (ILD) than those with normal levels. Moreover, in SSc patients, serum IL-34 levels negatively correlated with the percentage of predicted vital capacity, while they positively correlated with ground-glass opacity score and fibrotic score on chest computed tomography. Collectively, increased serum IL-34 levels were associated with greater frequency and severity of ILD in SSc patients. Serum IL-34 levels may be a useful serological marker for SSc-associated ILD.
白细胞介素 (IL)-34 是一种促造血细胞因子，可促进巨噬细胞的增殖和分化。由于巨噬细胞的异常激活与系统性硬化症 (SSc) 的发展有关，我们研究了 SSc 患者的血清 IL-34 水平。与局限性皮肤 SSc 和健康对照组相比，弥漫性皮肤 SSc 患者的血清 IL-34 水平显著升高，而局限性皮肤 SSc 和健康对照组之间则无显著差异。此外，血清 IL-34 水平升高的 SSc 患者更常发生间质性肺病 (ILD)，而非正常水平者。此外，在 SSc 患者中，血清 IL-34 水平与预计肺活量百分比呈负相关，而与胸部 CT 的磨玻璃影评分和纤维化评分呈正相关。综上所述，血清 IL-34 水平升高与 SSc 患者ILD 的频率和严重程度增加有关。血清 IL-34 水平可能是 SSc 相关ILD 的一种有用的血清学标志物。
