Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.
Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris.
Eur J Neurol. 2018 Nov;25(11):1378-1383. doi: 10.1111/ene.13753. Epub 2018 Aug 16.
Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies.
This was a monocentric retrospective observational study. Inclusion criteria for idiopathic ON were as follows: age ≥ 16 years, follow-up of at least 2 years, negative for antibodies against MOG and AQP4 immunoglobulin G, and no magnetic resonance imaging (MRI) lesions suggestive of demyelination (two brain MRI scans, one at baseline and one during follow-up, and one spinal cord MRI scan).
Among 23 patients with idiopathic ON (female, 82.6%; median age, 36 years; median follow-up time, 41.4 months), 56.5% had recurrent ON (median time to a second ON episode, 6 months). The final visual acuity in this group (median, 0; mean, 0.43; range, 0-3) was similar to that in the AQP4 group (n = 18; P-value after Bonferroni correction = 0.936) but worse than that in the MOG group (n = 25; P-value after Bonferroni correction = 0.019). At the last evaluation, visual acuity levels were ≤0.5 and <0.2, respectively, in 36.8% and 21% of the idiopathic ON group, 58.3% and 26.7% of the AQP4 group, and 0% and 0% of the MOG group.
The recovery of visual acuity among patients with idiopathic ON was poor, similar to that observed in the AQP4 group.
目前关于特发性视神经炎（ON）的研究数据较少。我们旨在描述大量特发性 ON 患者的情况。我们将该队列与髓鞘少突胶质细胞糖蛋白（MOG）相关 ON 或水通道蛋白 4（AQP4）抗体相关 ON 患者进行了比较。
这是一项单中心回顾性观察性研究。特发性 ON 的纳入标准如下：年龄≥16 岁，至少随访 2 年，MOG 和 AQP4 免疫球蛋白 G 抗体阴性，无提示脱髓鞘的磁共振成像（MRI）病变（2 次脑部 MRI 扫描，1 次基线，1 次随访，1 次脊髓 MRI 扫描）。
在 23 例特发性 ON 患者（女性占 82.6%；中位年龄为 36 岁；中位随访时间为 41.4 个月）中，56.5%的患者有复发性 ON（第二次 ON 发作的中位时间为 6 个月）。该组的最终视力（中位数，0；平均值，0.43；范围，0-3）与 AQP4 组相似（经 Bonferroni 校正后的 P 值=0.936），但低于 MOG 组（经 Bonferroni 校正后的 P 值=0.019）。在最后一次评估时，特发性 ON 组分别有 36.8%和 21%的患者视力水平≤0.5 和<0.2，AQP4 组分别有 58.3%和 26.7%的患者视力水平≤0.5 和<0.2，而 MOG 组无患者视力水平≤0.5 和<0.2。
特发性 ON 患者的视力恢复较差，与 AQP4 组相似。
