Department of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, China.
Psychiatry Res. 2018 Oct;268:60-64. doi: 10.1016/j.psychres.2018.06.069. Epub 2018 Jul 4.
The proteomic study reported that Tenascin-C might be a diagnostic biomarker for major depressive disorder, but clinical studies of this potential relationship are lacking. Here we examined the association between tenascin-C levels in serum and suicide attempts. Serum tenascin-C concentrations were compared among depressive patients who had not attempted suicide (n = 86), patients who had attempted it (n = 43), and healthy controls (n = 109). All participants were aged between 18 and 68 years. The association between concentration and suicide attempts was assessed by multivariate analysis after adjusting for sociodemographics, lifestyle and health indicators. Tenascin-C concentrations were higher in patients than in controls, and higher in patients who had attempted suicide than in patients who had not. Higher concentrations were associated with greater risk of attempting suicide. Among patients who had attempted suicide, tenascin-C concentrations were associated with severity of depression. Our results suggest that high tenascin-C levels in depressive patients correlate with suicide attempts and severity of depression. Tenascin-C may contribute to risk of suicide attempts in depressed patients.
这项蛋白质组学研究表明 Tenascin-C 可能是重度抑郁症的一个诊断生物标志物，但缺乏关于这种潜在关系的临床研究。在这里，我们研究了血清中 Tenascin-C 水平与自杀未遂之间的关系。我们比较了未发生自杀未遂的抑郁患者（n=86）、发生过自杀未遂的患者（n=43）和健康对照者（n=109）的血清 Tenascin-C 浓度。所有参与者年龄在 18 至 68 岁之间。在调整了社会人口统计学、生活方式和健康指标后，通过多变量分析评估了浓度与自杀未遂之间的关联。与对照组相比，患者的 Tenascin-C 浓度更高，与未发生自杀未遂的患者相比，发生过自杀未遂的患者的 Tenascin-C 浓度更高。较高的浓度与自杀未遂的风险增加相关。在发生过自杀未遂的患者中，Tenascin-C 浓度与抑郁的严重程度相关。我们的结果表明，抑郁患者中高水平的 Tenascin-C 与自杀未遂和抑郁严重程度相关。Tenascin-C 可能导致抑郁患者自杀未遂的风险增加。
