High serum levels of tenascin-C are associated with suicide attempts in depressed patients.

The proteomic study reported that Tenascin-C might be a diagnostic biomarker for major depressive disorder, but clinical studies of this potential relationship are lacking. Here we examined the association between tenascin-C levels in serum and suicide attempts. Serum tenascin-C concentrations were compared among depressive patients who had not attempted suicide (n = 86), patients who had attempted it (n = 43), and healthy controls (n = 109). All participants were aged between 18 and 68 years. The association between concentration and suicide attempts was assessed by multivariate analysis after adjusting for sociodemographics, lifestyle and health indicators. Tenascin-C concentrations were higher in patients than in controls, and higher in patients who had attempted suicide than in patients who had not. Higher concentrations were associated with greater risk of attempting suicide. Among patients who had attempted suicide, tenascin-C concentrations were associated with severity of depression. Our results suggest that high tenascin-C levels in depressive patients correlate with suicide attempts and severity of depression. Tenascin-C may contribute to risk of suicide attempts in depressed patients.