Tan Marisela, Kalin-Hajdu Evan, Narayan Rupa, Wong Sandy W, Martin Thomas G
1 Department of Pharmaceutical Services, Division of Hematology/Oncology, University of California, San Francisco, CA, USA.
2 Department of Ophthalmology, Division of Hematology/Oncology, University of California, San Francisco, CA, USA.
J Oncol Pharm Pract. 2019 Jul;25(5):1253-1257. doi: 10.1177/1078155218785967. Epub 2018 Jul 13.
Multiple myeloma is a cancer of malignant plasma cells which stimulates osteoclasts and is associated with increased bone turnover and osteolysis. Bisphosphonates including zolendronic acid are used to prevent skeletal complications in patients with multiple myeloma. Orbital inflammation is a rare but serious complication following use of bisphosphonates. The diagnosis is made by excluding other possible causes in patients with myeloma and rapid initiation of therapy is required. Corticosteroids are the mainstay of therapy but the ideal treatment course has not been delineated. This report describes a case of this rare complication and provides a review of the literature.
多发性骨髓瘤是一种恶性浆细胞癌，可刺激破骨细胞，与骨转换增加和骨质溶解有关。包括唑来膦酸在内的双膦酸盐用于预防多发性骨髓瘤患者的骨骼并发症。眼眶炎症是使用双膦酸盐后罕见但严重的并发症。通过排除骨髓瘤患者的其他可能病因来做出诊断，且需要迅速开始治疗。皮质类固醇是主要治疗方法，但理想的治疗疗程尚未明确。本报告描述了这一罕见并发症的病例并对文献进行了综述。
