Department of Breast Surgical Oncology, University of Texas M.D. Anderson Cancer Center, 1400 Pressler Street, Unit 1434, Houston, TX 77030, USA.
Surg Clin North Am. 2018 Aug;98(4):859-868. doi: 10.1016/j.suc.2018.03.012.
The role of operative therapy in stage IV breast cancer continues to evolve with advances in therapy and improvements in survival among this population. Traditionally surgery was performed with palliative intent to alleviate symptoms related to the intact breast primary. Several retrospective studies have challenged this paradigm, demonstrating survival advantage with surgery in de novo metastatic disease. Prospective studies are ongoing and maturing data. A comprehensive approach to local therapy following systemic therapy may be beneficial to achieve improved survival outcome associated with stage IV- no evidence of disease and to decrease local failure in inflammatory breast cancer.
手术治疗在 IV 期乳腺癌中的作用随着治疗的进展和该人群生存率的提高而不断演变。传统上，手术是为了缓解与完整乳房原发性相关的症状而进行的姑息性治疗。几项回顾性研究对这一模式提出了挑战，表明在新诊断的转移性疾病中手术具有生存优势。正在进行和成熟的数据的前瞻性研究。在全身治疗后采用综合方法进行局部治疗可能有助于改善与 IV 期无疾病证据相关的生存结果，并降低炎性乳腺癌的局部失败率。
