Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Germany; The FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Finland.
Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Germany; Core-Facility Brainimaging, Faculty of Medicine, Philipps University of Marburg, Germany.
Neuroscience. 2018 Nov 10;392:219-229. doi: 10.1016/j.neuroscience.2018.06.045. Epub 2018 Jul 11.
The successful recovery from affective loss (i.e., bereavement, relationship breakup) has been linked to adult attachment style (AAS), a personality trait. Up to now, the association between AAS, affective loss experiences and brain gray matter volume is unclear. In 192 healthy subjects we investigated the association between MRI brain gray matter volume, applying voxel based morphometry, AAS (Relationship Scales Questionnaire (RSQ), subscales "avoidance" (AV) and "anxiety" (ANX)), and number of affective losses within the last 5 years (AL; List of Threatening Experiences Questionnaire). In a whole-brain analysis (p < 0.05 FWE-corrected) ANX compared to AV was significantly more positively associated with brain gray matter volume in the left insula and in the pars opercularis of left inferior frontal gyrus. In additional region-of-interest (ROI) analyses (p < 0.05 FWE-corrected), based on previously reported findings, no significant associations were observed. ANX and AV differently correlate with local volumes of the left insula and pars opercularis of the left inferior frontal gyrus, which are implicated in emotion processing, empathy and emotion regulation among other functions. Our results support the notion that individual attachment styles, which develop in the interplay of genes and social environment, differ in their correlation with brain structure.
从情感丧失（例如丧亲、关系破裂）中成功恢复与成人依恋风格（AAS）有关，这是一种个性特征。到目前为止，AAS、情感丧失经历和大脑灰质体积之间的关联尚不清楚。在 192 名健康受试者中，我们调查了 MRI 大脑灰质体积、应用基于体素的形态计量学、AAS（关系量表问卷（RSQ），子量表“回避”（AV）和“焦虑”（ANX））以及过去 5 年内情感丧失次数（AL；威胁经验清单）之间的关联。在全脑分析中（p < 0.05 FWE 校正），与 AV 相比，ANX 与左侧脑岛和左侧额下回的口角回的大脑灰质体积呈更显著的正相关。在基于先前报道发现的额外的感兴趣区域（ROI）分析中（p < 0.05 FWE 校正），未观察到显著的关联。ANX 和 AV 与左侧脑岛和左侧额下回的口角回的局部体积呈不同的相关性，这些区域与情绪处理、同理心和情绪调节等功能有关。我们的研究结果支持这样一种观点，即个体依恋风格是在基因和社会环境的相互作用中发展起来的，它们与大脑结构的相关性存在差异。
