转移性和非转移性乳腺癌患者中癌-睾丸抗原转录活性的特异性特征
Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer.
作者信息
Vodolazhsky D I, Kutilin D S, Mogushkova Kh A, Kit O I
机构信息
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
出版信息
Bull Exp Biol Med. 2018 Jul;165(3):382-385. doi: 10.1007/s10517-018-4175-x. Epub 2018 Jul 14.
Cancer-testis antigens, effective markers of tissue malignant transformation, are characterized by heterogonous transcription depending on the pathological features of breast cancer. We performed screening of transcription profile of cancer-testis antigens specific for breast tumor tissues in female patients with and without regional metastasis. The relative expression of 16 genes (MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NY-ESO1, SSX2, SYCP1, and PRAME1) was analyzed by RT-qPCR method in biopsy specimens of the mammary gland tissues obtained during surgery from 25 patients. Differential transcription activity of cancer-testis antigens genes was observed in patients with metastatic (enhanced expression of MAGEA2, MAGEB1, and XAGE3 genes) and non-metastatic (enhanced expression of GAGE3 and PRAME1 genes) breast cancer.
癌-睾丸抗原是组织恶性转化的有效标志物，其特征是根据乳腺癌的病理特征进行异源转录。我们对有或无区域转移的女性乳腺癌患者乳腺肿瘤组织特异性的癌-睾丸抗原转录谱进行了筛查。采用RT-qPCR方法分析了25例患者手术获取的乳腺组织活检标本中16个基因（MAGEA1、MAGEA2、MAGEA3、MAGEA4、MAGEB1、MAGEB2、GAGE1、GAGE3、GAGE4、MAGEC1、BAGE、XAGE3、NY-ESO1、SSX2、SYCP1和PRAME1）的相对表达。在转移性（MAGEA2、MAGEB1和XAGE3基因表达增强）和非转移性（GAGE3和PRAME1基因表达增强）乳腺癌患者中观察到癌-睾丸抗原基因的差异转录活性。
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