DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Cluster of Excellence, Dresden, Germany.
DFG-Center for Regenerative Therapies Technische Universität Dresden (CRTD), Cluster of Excellence, Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Curr Opin Cell Biol. 2018 Dec;55:74-80. doi: 10.1016/j.ceb.2018.05.014. Epub 2018 Jul 11.
Cellular senescence is a ubiquitous stress response that restricts the proliferative capacity of cells. During ageing, senescent cells accumulate in various tissues leading to a number of age-related pathologies and physiological decline. Previously thought to be a process restricted to adult organisms, cellular senescence has been recently demonstrated to occur during embryonic development of animals ranging from fish to mammals. Together, these studies suggest that developmentally programmed senescence is a transient but intrinsic biological process that contributes to the remodelling of developing structures by promoting immune-mediated cell clearance of particular cell populations or modifying the tissue microenvironment. These observations have important implications for the evolutionary origins of this essential, yet paradoxical mechanism.
细胞衰老（cellular senescence）是一种普遍存在的应激反应，限制了细胞的增殖能力。在衰老过程中，衰老细胞在各种组织中积累，导致许多与年龄相关的病理和生理衰退。过去认为细胞衰老仅限于成年生物体，但最近的研究表明，从鱼类到哺乳动物等动物的胚胎发育过程中也会发生细胞衰老。这些研究表明，发育编程性衰老（developmentally programmed senescence）是一种短暂但内在的生物学过程，通过促进免疫介导的特定细胞群体的细胞清除或改变组织微环境，有助于发育结构的重塑。这些观察结果对这一重要但矛盾的机制的进化起源具有重要意义。
