鸡体内与脑相关的胸腺抗原。

Brain-associated thymic antigen in chickens.

作者信息

Barnett J M, Glick B

出版信息

Int Arch Allergy Appl Immunol. 1977;53(1):11-7. doi: 10.1159/000231725.

Abstract

Sera were produced in rabbits against a saline extract of chicken embryo brain (CBE). The rabbit anti-chicken brain (RACB) sera revealed, in micro-Ouchterlony studies, brain-associated antigens in extracts from the thymus, bursa, spleen and kidney. Absorption of the sera with normal serum (ns) and kidney (K), (RACBns, K), removed all reactivity with tissues other than brain. However, cytotoxic studies demonstrated that the kidney-absorbed serum was toxic to lymphocytes from thymus, bursa and spleen. Proper dilution of the RACBns, K produced a serum which was more cytotoxic for thymic lymphocytes than bursal lymphocytes. This study indicates the presence of brain-associated thymic antigens in the chicken.

摘要

用鸡胚脑（CBE）的盐溶液提取物在兔子体内制备血清。在微量双向免疫扩散研究中，兔抗鸡脑（RACB）血清显示，胸腺、法氏囊、脾脏和肾脏提取物中存在脑相关抗原。用正常血清（ns）和肾脏（K）吸收血清（RACBns，K）后，消除了与脑以外组织的所有反应性。然而，细胞毒性研究表明，肾脏吸收的血清对来自胸腺、法氏囊和脾脏的淋巴细胞有毒性。适当稀释RACBns，K产生的血清对胸腺淋巴细胞的细胞毒性比对法氏囊淋巴细胞的细胞毒性更大。这项研究表明鸡体内存在脑相关胸腺抗原。