阿拉伯糖基胸腺嘧啶：体外脾淋巴细胞大分子合成的抑制剂。
Arabinosylthymine: inhibitor of splenic lymphocyte macromolecular synthesis in vitro.
作者信息
Barnett J M, McGowan J J, Gentry G A
出版信息
Infect Immun. 1979 Oct;26(1):294-7. doi: 10.1128/iai.26.1.294-297.1979.
Abstract
The effect of arabinosylthymine on lymphocyte transformation was investigated. Arabinosylthymine was demonstrated not to be cytotoxic for hamster spleen lymphocytes but was found to inhibit the increase in deoxyribonucleic acid and protein synthesis usually observed as a result of mitogen stimulation. These findings suggest that, in addition to being a potent anti-herpesvirus inhibitor, arabinosylthymine is also an immunosuppressive agent.
摘要
研究了阿糖胸苷对淋巴细胞转化的影响。结果表明，阿糖胸苷对仓鼠脾淋巴细胞无细胞毒性，但发现它能抑制通常因有丝分裂原刺激而观察到的脱氧核糖核酸和蛋白质合成的增加。这些发现表明，阿糖胸苷除了是一种有效的抗疱疹病毒抑制剂外，也是一种免疫抑制剂。
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Chem Biol Interact. 1978 Nov;23(2):151-8. doi: 10.1016/0009-2797(78)90002-9.
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Virology. 1979 Jan 30;92(2):367-74. doi: 10.1016/0042-6822(79)90141-7.
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