University Grenoble Alpes, SyNaBi, TIMC-IMAG/CNRS/INSERM, UMR 5525, F-38000 Grenoble, France.
School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS London, UK.
Bioelectrochemistry. 2018 Dec;124:57-72. doi: 10.1016/j.bioelechem.2018.05.011. Epub 2018 Jun 18.
There is a growing interest in the design and engineering of operational biofuel cells that can be implanted. This review highlights the recent progress in the electrochemistry of biofuel cell technologies, but with a particular emphasis on the medical and physiological aspects that impact the biocompatibility of biofuel cells operating inside a living body. We discuss the challenge of supplying power to implantable medical devices, with regard to the limitations of lithium battery technology and why implantable biofuel cells can be a promising alternative to provide the levels of power required for medical devices. In addition to the challenge of designing a biofuel cell that provides a stable level of sufficient power, the review highlights the biocompatibility and biofouling problems of implanting a biofuel cell that have a major impact on the availability of the substrates inside body that provide fuel for the biofuel cell. These physiological challenges and associated ethical considerations are essential to consider for biofuel cells that are designed to be implanted for long-term operation inside a living animal and eventually to human clinical applications.
人们对可植入式操作型生物燃料电池的设计和工程越来越感兴趣。本综述重点介绍了生物燃料电池技术电化学领域的最新进展，但特别强调了影响生物燃料电池在体内生物相容性的医学和生理方面。我们讨论了为植入式医疗设备供电的挑战，包括锂电池技术的局限性，以及为什么植入式生物燃料电池可以作为一种有前途的替代方案，为医疗设备提供所需的电力水平。除了设计提供稳定充足电力水平的生物燃料电池的挑战外，该综述还强调了植入生物燃料电池的生物相容性和生物污垢问题，这对为生物燃料电池提供燃料的体内底物的可用性有重大影响。对于设计用于在活体动物体内长期运行并最终应用于人类临床的植入式生物燃料电池，这些生理挑战和相关的伦理考虑是必不可少的。
