mRNA 和非编码 RNA 中的 N6-甲基腺苷甲基组。
N-methyladenosine methylome in messenger RNA and non-coding RNA.
机构信息
State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, PR China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
出版信息
Curr Opin Chem Biol. 2018 Aug;45:179-186. doi: 10.1016/j.cbpa.2018.06.017. Epub 2018 Jul 9.
Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N-methyladenosine (mA), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA. mA in these abundant non-coding RNAs plays important roles in maintaining their biological functions. Recent studies also reveal that mA is present in both nuclear-encoded and mitochondrial-encoded mRNA and is dynamically regulated by environmental and developmental conditions; mA is found in a subset of nuclear-encoded long non-coding RNAs as well. Finally, we also discuss the potential challenges of identifying mA modification in the human transcriptome.
RNA 化学修饰为基因表达提供了一个新的调控层，被称为“转录后组”。N6-甲基腺苷（m6A），50 多年前首次被描述，是 rRNA 和 tRNA 中一种众所周知的修饰。这些丰富的非编码 RNA 中的 m6A 对于维持其生物学功能起着重要作用。最近的研究还表明，m6A 存在于核编码和线粒体编码的 mRNA 中，并受到环境和发育条件的动态调节；m6A 也存在于一部分核编码的长非编码 RNA 中。最后，我们还讨论了在人类转录组中鉴定 m6A 修饰的潜在挑战。
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