Unidad de Gestión Clínica de Obstetricia y Ginecología, Hospital Universitario Araba, Vitoria, Spain; Universidad del País Vasco, Vitoria, Spain.
Clínica Margen, Granada, Spain; Universidad de Granada, Granada, Spain.
Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:221-224. doi: 10.1016/j.ejogrb.2018.07.002. Epub 2018 Jul 6.
To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain.
Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain.
In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7% of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months of treatment, this percentage decreased to 87.2% (p = 0.074) and at 6 months the percentage was 82.7% (p < 0.05).
Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.
评估含有 N-乙酰半胱氨酸、α-硫辛酸和菠萝蛋白酶的抗氧化剂制剂对子宫内膜异位症相关盆腔疼痛的影响。
在具有子宫内膜异位症相关盆腔疼痛的代表性女性样本中进行的多中心、开放标签、非对照临床试验。
共有 398 名平均年龄为 34.6±7.2 岁的患者接受了 N-乙酰半胱氨酸、α-硫辛酸和菠萝蛋白酶的联合治疗，为期 6 个月。在基线时，92.7%的患者视觉模拟评分（VAS）上的疼痛强度>4；治疗 3 个月后，这一比例下降至 87.2%（p=0.074），6 个月时为 82.7%（p<0.05）。
希望怀孕并接受含有 N-乙酰半胱氨酸、α-硫辛酸和菠萝蛋白酶的制剂治疗的子宫内膜异位症患者，其子宫内膜异位症相关盆腔疼痛显著改善，并且需要较低剂量的解救性镇痛药。
