Complejo Hospitalario de Navarra: Radiotherapeutic Oncology Department, Irunlarrea 3, 31008 Pamplona, Spain; Complejo Hospitalario de Navarra: Medical Oncology Department, Irunlarrea 3, 31008 Pamplona, Spain.
Complejo Hospitalario de Navarra: Radiotherapeutic Oncology Department, Irunlarrea 3, 31008 Pamplona, Spain.
Breast. 2018 Oct;41:74-81. doi: 10.1016/j.breast.2018.06.010. Epub 2018 Jun 22.
This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups.
Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT. Longitudinal changes in QL were assessed for the whole sample using linear mixed-effect models. Also assessed were differences in QL scores between axillary treatment groups (axillary node dissection ALND, sentinel lymph node biopsy SLNB, and no surgery) at the end of the follow-up (Anova or Kruskal-Wallis) and differences in the evolution of QL from baseline among these groups (linear regression models).
QL scores in the follow-up were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment. Five areas (pain, nausea/vomiting, financial impact, breast symptoms and IDDD) improved significantly (<6 points) in the follow-up. The ALND group scored less for the future perspective item (15-20 points) in the follow-up than the other two axillary treatment groups. No differences between the pre-treatment and follow up assessments regarding treatment were found among the axillary treatment groups.
Our results suggest that early-stage breast cancer patients adapted well both to their disease and treatments over the follow-up period and to the administration of RT. There were few QL differences between the axillary treatment groups.
本研究旨在探讨老年早期乳腺癌幸存者的生活质量（QL）。目的是比较这些患者在随访后的 QL 评分与放疗（RT）前的评分，并比较不同腋窝治疗组之间的 QL。
在 173 名 65 岁以上开始治疗并完成 EORTC QLQ-C30 和 QLQ-BR23 以及在 RT 前进行的痴呆日常生活活动恶化访谈（IDDD）的患者中，有 138 名患者在 RT 后三年也完成了这些问卷。使用线性混合效应模型评估整个样本的 QL 纵向变化。还评估了腋窝治疗组（腋窝淋巴结清扫术 ALND、前哨淋巴结活检术 SLNB 和无手术）在随访结束时的 QL 评分差异（方差分析或 Kruskal-Wallis）以及这些组中从基线到 QL 的演变差异（线性回归模型）。
在大多数 QL 领域，随访中的 QL 评分较高（>70/100 分），性功能和享受方面存在中度限制（>30）。在随访中，有五个领域（疼痛、恶心/呕吐、经济影响、乳房症状和 IDDD）显著改善（<6 分）。ALND 组在随访中未来展望项目的评分（15-20 分）低于其他两个腋窝治疗组。在腋窝治疗组中，治疗前后评估在治疗方面没有差异。
我们的研究结果表明，早期乳腺癌患者在随访期间很好地适应了疾病和治疗，并很好地适应了 RT 的实施。腋窝治疗组之间的 QL 差异很少。
