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对3251例急诊开胸手术的系统评价:是时候建立一个全国性数据库了吗?

A systematic review of 3251 emergency department thoracotomies: is it time for a national database?

作者信息

Nevins Edward John, Bird Nicholas Thomas Edward, Malik Hassan Zakria, Mercer Simon Jude, Shahzad Khalid, Lunevicius Raimundas, Taylor John Vincent, Misra Nikhil

机构信息

Emergency General Surgery and Trauma Unit, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK.

Liverpool Medical School, University of Liverpool, Liverpool, UK.

出版信息

Eur J Trauma Emerg Surg. 2019 Apr;45(2):231-243. doi: 10.1007/s00068-018-0982-z. Epub 2018 Jul 14.

Abstract

PURPOSE

Emergency department thoracotomy (EDT) is a potentially life-saving procedure, performed on patients suffering traumatic cardiac arrest. Multiple indications have been reported, but overall survival remains unclear for each indication. The objective of this systematic review is to determine overall survival, survival stratified by indication, and survival stratified by geographical location for patients undergoing EDT across the world.

METHODS

Articles published between 2000 and 2016 were identified which detailed outcomes from EDT. All articles referring to pre-hospital, delayed, or operating room thoracotomy were excluded. Pooled odds ratios (OR) were calculated comparing differing indications.

RESULTS

Thirty-seven articles, containing 3251 patients who underwent EDT, were identified. There were 277 (8.5%) survivors. OR demonstrate improved survival for; penetrating vs blunt trauma (OR 2.10; p 0.0028); stab vs gun-shot (OR 5.45; p < 0.0001); signs of life (SOL) on admission vs no SOL (OR 5.36; p < 0.0001); and SOL in the field vs no SOL (OR 19.39; p < 0.0001). Equivalence of survival was demonstrated between cardiothoracic vs non-cardiothoracic injury (OR 1.038; p 1.000). Survival was worse for USA vs non-USA cohorts (OR 1.59; p 0.0012).

CONCLUSIONS

Penetrating injury remains a robust indication for EDT. Non-cardiothoracic cause of cardiac arrest should not preclude EDT. In the absence of on scene SOL, survival following EDT is extremely unlikely. Survival is significantly higher in the non-USA publications; reasons for this are highly complex. A UK multicentre prospective study which collects standardised data on all EDTs could provide robust evidence for better patient stratification.

摘要

目的

急诊开胸手术(EDT)是一种对创伤性心脏骤停患者实施的、有可能挽救生命的手术。已报道了多种适应症,但每种适应症的总体生存率仍不明确。本系统评价的目的是确定全球接受EDT患者的总体生存率、按适应症分层的生存率以及按地理位置分层的生存率。

方法

确定2000年至2016年发表的详细报道EDT结果的文章。排除所有提及院前、延迟或手术室开胸手术的文章。计算合并比值比(OR)以比较不同的适应症。

结果

共确定了37篇文章,包含3251例接受EDT的患者。有277例(8.5%)幸存者。OR显示以下情况生存率提高:穿透伤与钝性伤(OR 2.10;p 0.0028);刺伤与枪伤(OR 5.45;p<0.0001);入院时有生命体征(SOL)与无SOL(OR 5.36;p<0.0001);现场有SOL与无SOL(OR 19.39;p<0.0001)。心胸损伤与非心胸损伤的生存率相当(OR 1.038;p 1.000)。美国队列与非美国队列的生存率更低(OR 1.59;p 0.0012)。

结论

穿透伤仍然是EDT的有力适应症。心脏骤停的非心胸原因不应排除EDT。在现场无SOL的情况下,EDT后存活的可能性极小。非美国出版物中的生存率显著更高;其原因非常复杂。一项收集所有EDT标准化数据的英国多中心前瞻性研究可为更好地对患者进行分层提供有力证据。

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