具有C端硫代酰胺基团的促甲状腺激素释放激素类似物。合成、受体结合、促甲状腺激素释放活性及α-促黑素细胞激素释放活性
TRH analogue with C-terminal thioamide group. Synthesis, receptor binding, TSH-releasing activity and alpha-MSH-releasing activity.
作者信息
Kruszyński M, Kupryszewski G, Ragnarsson U, Alexandrova M, Strbak V, Tonon M C, Vaudry H
出版信息
Experientia. 1985 Dec 15;41(12):1576-7. doi: 10.1007/BF01964815.
PMID:3000815
Abstract
A new TRH analogue containing a C-terminal thioamide group was synthesized. This peptide was shown to have receptor-binding affinity, and TSH- as well as alpha-MSH-releasing activities very similar to native TRH.
摘要
合成了一种含有C端硫代酰胺基团的新型促甲状腺激素释放激素（TRH）类似物。该肽显示出具有受体结合亲和力，并且其促甲状腺激素（TSH）释放活性以及α-促黑素细胞激素（α-MSH）释放活性与天然TRH非常相似。
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