Gerasina S F, Farashian V R, Fadeeva N I, Ugarova T Iu
Farmakol Toksikol. 1985 Sep-Oct;48(5):92-6.
Inhibition of the synthesis of virus-specific proteins of influenza A/WSN/33 virus in the cells of chick embryo fibroblasts and in continuous cells of dog embryonal kidney was discovered as was a negligible inhibition of the synthesis of cell proteins in the presence of an original synthetic antivirus drug bonaphthon. Experiments were made to attain selective inhibition of individual virus-specific proteins of influenza virus in these cultures. In model experiments in vitro in a cell-free protein-synthesizing system, bonaphthon was demonstrated to inhibit translation of RNA-virus of encephalomyocarditis on the virus template without affecting translation on the cell template of hemoglobin mRNA.
在鸡胚成纤维细胞和犬胚肾连续细胞中发现，一种原合成抗病毒药物波纳芬可抑制甲型流感病毒A/WSN/33病毒特异性蛋白的合成，而对细胞蛋白合成的抑制作用可忽略不计。在这些培养物中进行了实验，以实现对流感病毒个别病毒特异性蛋白的选择性抑制。在无细胞蛋白质合成系统的体外模型实验中，已证明波纳芬可抑制脑心肌炎RNA病毒在病毒模板上的翻译，而不影响血红蛋白mRNA在细胞模板上的翻译。
